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==Issue== [[File:Family tree of King James I and VI of England and Scotland.jpg|thumb|alt=A painting of a family tree consisting of fourteen oval portraits arranged in five rows with two in the first and last rows, four in the middle row, and three in the other two rows|upright|A family tree depicting James's ancestors]] Anne gave birth to seven children who survived beyond childbirth, four of whom died in infancy or early childhood.{{Sfnp|Stewart|2003|pp=140, 142}} She also suffered at least three miscarriages.{{Sfnp|Williams|1970|p=112}} The physician [[Martin SchΓΆner]] attended her pregnancies.{{Sfnp|Field|2020|p=184}} Her second son succeeded James as [[Charles I of England|King Charles I]]. Her daughter [[Elizabeth of Bohemia|Elizabeth]] was the "Winter Queen" of Bohemia and the grandmother of [[King George I of Great Britain]]. # miscarriage (September 1590) # [[Henry Frederick, Prince of Wales]] (19 February 1594 β 6 November 1612). Died, probably of [[typhoid fever]], aged 18.{{Efn|[[John Chamberlain (letter writer)|John Chamberlain]] recorded: "It was verily thought that the disease was no other than the ordinary [[wikt:ague|ague]] that had reigned and raged all over England". Alan Stewart writes that latter-day experts have suggested [[enteric fever]], typhoid fever, or [[porphyria]], but that at the time poison was the most popular explanation.{{Sfnp|Stewart|2003|p=248}}}} # miscarriage (July 1595). # [[Elizabeth, Queen of Bohemia]] (19 August 1596 β 13 February 1662). Married 1613, [[Frederick V, Elector Palatine]]. Died aged 65. # [[Margaret Stuart (1598β1600)|Margaret]] (24 December 1598 [[Dalkeith Palace]] β March 1600 [[Linlithgow Palace]]). Died aged fifteen months. Buried at [[Holyrood Abbey]]. # [[Charles I of England|Charles I, King of England, Scotland and Ireland]] (19 November 1600 β 30 January 1649). Married 1625, [[Henrietta Maria of France]]. Executed aged 48. # [[Robert Stuart, Duke of Kintyre|Robert, Duke of Kintyre]] (18 January 1602 β 27 May 1602). Died aged four months.{{Sfnp|Willson|1963|p=452}}{{Sfnp|Barroll|2001|p=27}} # miscarriage (10 May 1603).<ref>[[Nadine Akkerman]], ''Elizabeth Stuart, Queen of Hearts'' (Oxford, 2021), pp. 26β7, 417 fn.54.</ref> # [[Mary Stuart (1605β1607)|Mary]] (8 April 1605 [[Greenwich Palace]] β 16 December 1607 [[Stanwell]], Surrey). Died aged two. # [[Sophia Stuart (1606)|Sophia]] (22 June 1606 β 23 June 1606). Born and died at [[Greenwich Palace]].{{Sfnp|Croft|2003|page=24}}{{Sfnp|Stewart|2003|p=142}} Sophia was buried at [[Henry VII Lady Chapel|King Henry's Chapel]] in a tiny alabaster tomb shaped like a cradle, designed by [[Maximilian Colt]].{{Sfnp|Williams|1970|page=112}}{{Sfnp|Willson|1963|p=456}} {{clear}}
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