Editing Tacrolimus (section)

===Organ transplantation===
It has similar immunosuppressive properties to [[ciclosporin]], but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study.<ref name="Medscape2004-McCauley">{{cite web | vauthors = McCauley J |date=19 May 2004 | url = http://www.medscape.com/viewarticle/474429 | title=Long-Term Graft Survival In Kidney Transplant Recipients | work=Slide Set Series on Analyses of Immunosuppressive Therapies | publisher=[[Medscape]] | access-date=6 June 2006}}</ref> Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation.<ref>{{cite journal | vauthors = Haddad EM, McAlister VC, Renouf E, Malthaner R, Kjaer MS, Gluud LL | title = Cyclosporin versus tacrolimus for liver transplanted patients | journal = The Cochrane Database of Systematic Reviews | volume = 2006 | issue = 4 | pages = CD005161 | date = October 2006 | pmid = 17054241 | pmc = 8865611 | doi = 10.1002/14651858.CD005161.pub2 | veditors = McAlister V }}</ref><ref>{{cite journal | vauthors = O'Grady JG, Burroughs A, Hardy P, Elbourne D, Truesdale A | title = Tacrolimus versus microemulsified ciclosporin in liver transplantation: the TMC randomised controlled trial | journal = Lancet | volume = 360 | issue = 9340 | pages = 1119–1125 | date = October 2002 | pmid = 12387959 | doi = 10.1016/S0140-6736(02)11196-2 | s2cid = 10417106 }}</ref> Long-term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including [[corticosteroids|steroids]], [[mycophenolate]], and [[IL-2 receptor]] inhibitors such as [[basiliximab]]. Dosages are titrated to target blood levels at specific times after medication administration.<ref>{{cite journal | vauthors = Lee MN, Butani L | title = Improved pharmacokinetic monitoring of tacrolimus exposure after pediatric renal transplantation | journal = Pediatric Transplantation | volume = 11 | issue = 4 | pages = 388–393 | date = June 2007 | pmid = 17493218 | doi = 10.1111/j.1399-3046.2006.00618.x | s2cid = 23530214 | doi-access = free }}</ref>