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==Energy (caloric) content== The energy content of a single-serving (1 g packet) of Splenda is 3.36 kcal, which is 31% of a single-serving (2.8 g packet) of granulated sugar (10.8 kcal).<ref name=NDL/> In the United States, it is legally labelled "zero calories";<ref name=NDL>{{cite web| url = https://fdc.nal.usda.gov/fdc-app.html#/food-details/170257/nutrients| title = USDA FoodData Central}} [[United States Department of Agriculture]]</ref> U.S. [[Food and Drug Administration|FDA]] regulations allow this "if the food contains less than 5 Calories per reference amount customarily consumed and per labeled serving".<ref>[http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=101.60 Code of Federal Regulations, Title 21, Volume 2, Pg. 95 β 101.60] U.S. Food and Drug Administration</ref> Splenda powder consists of predominantly fillers as [[Bulking agent|bulking agents]] β [[dextrose]] and [[maltodextrin]]. Sucralose content is about 1.1% and remainder is bulking agents.<ref>{{Cite journal |last1=Abou-Donia |first1=Mohamed B. |last2=El-Masry |first2=Eman M. |last3=Abdel-Rahman |first3=Ali A. |last4=McLendon |first4=Roger E. |last5=Schiffman |first5=Susan S. |date=2008 |title=Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats |url=https://pubmed.ncbi.nlm.nih.gov/18800291/ |journal=Journal of Toxicology and Environmental Health. Part A |volume=71 |issue=21 |pages=1415β1429 |doi=10.1080/15287390802328630 |issn=1528-7394 |pmid=18800291|bibcode=2008JTEHA..71.1415A }}</ref>
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