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===Depression=== A variety of meta-analyses have been conducted to evaluate the efficacy of paroxetine in depression. They have variously concluded that paroxetine is superior or equivalent to placebo and that it is equivalent to other antidepressants.<ref>{{cite journal | vauthors = Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R, Watanabe N, Nakagawa A, Omori IM, McGuire H, Tansella M, Barbui C | title = Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis | journal = Lancet | volume = 373 | issue = 9665 | pages = 746β758 | date = February 2009 | pmid = 19185342 | doi = 10.1016/S0140-6736(09)60046-5 | s2cid = 35858125 }}</ref><ref>{{cite journal | vauthors = Fava M, Amsterdam JD, Deltito JA, Salzman C, Schwaller M, Dunner DL | title = A double-blind study of paroxetine, fluoxetine, and placebo in outpatients with major depression | journal = Annals of Clinical Psychiatry | volume = 10 | issue = 4 | pages = 145β150 | date = December 1998 | pmid = 9988054 | doi = 10.3109/10401239809147030 }}</ref><ref name="ReferenceF">{{cite journal | vauthors = Sugarman MA, Loree AM, Baltes BB, Grekin ER, Kirsch I | title = The efficacy of paroxetine and placebo in treating anxiety and depression: a meta-analysis of change on the Hamilton Rating Scales | journal = PLOS ONE | volume = 9 | issue = 8 | pages = e106337 | date = 27 August 2014 | pmid = 25162656 | pmc = 4146610 | doi = 10.1371/journal.pone.0106337 | doi-access = free | bibcode = 2014PLoSO...9j6337S }}</ref> Despite this, there was no clear evidence that paroxetine was better or worse compared with other antidepressants at increasing response to treatment at any point in time.<ref>{{cite journal | vauthors = Purgato M, Papola D, Gastaldon C, Trespidi C, Magni LR, Rizzo C, Furukawa TA, Watanabe N, Cipriani A, Barbui C | title = Paroxetine versus other anti-depressive agents for depression | journal = The Cochrane Database of Systematic Reviews | issue = 4 | pages = CD006531 | date = April 2014 | volume = 2014 | pmid = 24696195 | doi = 10.1002/14651858.cd006531.pub2 | pmc = 10091826 | doi-access = free }}</ref>
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