Editing Paclitaxel (section)

===Similar compounds===
{{Further|Protein-bound paclitaxel|Docetaxel}}
Albumin-bound paclitaxel (brand name [[Abraxane]], also called nab-paclitaxel) is an alternative formulation where paclitaxel is bound to [[Human serum albumin|albumin]] nanoparticles. Much of the clinical toxicity of paclitaxel is associated with the solvent [[Cremophor EL]] in which it is dissolved for delivery.<ref>{{cite journal | vauthors = Gelderblom H, Verweij J, Nooter K, Sparreboom A | title = Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation | journal = European Journal of Cancer | volume = 37 | issue = 13 | pages = 1590–1598 | date = September 2001 | pmid = 11527683 | doi = 10.1016/S0959-8049(01)00171-X }}</ref>

[[Abraxis BioScience]] developed Abraxane, in which paclitaxel is bonded to [[Human serum albumin|albumin]] as an alternative delivery agent to the often toxic solvent delivery method. This was approved by the FDA in January 2005, for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within six months of adjuvant chemotherapy.<ref>{{cite web | title=Drug Approval Package: Abraxane (Pcalitaxel Protein-Bound Particles) NDA #021660 | website=U.S. [[Food and Drug Administration]] (FDA) | url=https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/21660_AbraxaneTOC.cfm | access-date=30 August 2024}}</ref> It has since been approved for locally advanced or metastatic non-small cell lung cancer and metastatic [[adenocarcinoma of the pancreas]] as well.<ref name="Abraxane FDA label" />

[[Taxane]]s, including paclitaxel, [[10-deacetylbaccatin III]], [[baccatin III]], paclitaxel C, and 7-epipaclitaxel, have been found in the leaves and shells of [[hazel]].<ref>{{cite journal | vauthors = Ottaggio L, Bestoso F, Armirotti A, Balbi A, Damonte G, Mazzei M, Sancandi M, Miele M | title = Taxanes from Shells and Leaves of Corylus avellana | journal = Journal of Natural Products | volume = 71 | issue = 1 | pages = 58–60 | date = January 2008 | pmid = 18163585 | doi = 10.1021/np0704046 | bibcode = 2008JNAtP..71...58O }}</ref> The finding of these compounds in shells, which are considered discarded material and are mass-produced by many food industries, is of interest for the future availability of paclitaxel.<ref name="pmid36227807">{{cite journal | vauthors = Zhang C, Yin G | title = Safety of paclitaxel-coated devices in the femoropopliteal arteries: A systematic review and meta-analysis | journal = PLOS ONE | volume = 17 | issue = 10 | pages = e0275888 | date = 2022 | pmid = 36227807 | pmc = 9560511 | doi = 10.1371/journal.pone.0275888 | bibcode = 2022PLoSO..1775888Z | doi-access = free }}</ref>