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=== Systems under research === Advances in lipid nanotechnology were instrumental in engineering medical nanodevices and novel drug delivery systems, as well as in developing sensing applications.<ref>{{cite journal | vauthors = Mashaghi S, Jadidi T, [[Gijsje Koenderink|Koenderink G]], Mashaghi A | title = Lipid nanotechnology | journal = International Journal of Molecular Sciences | volume = 14 | issue = 2 | pages = 4242β82 | date = February 2013 | pmid = 23429269 | pmc = 3588097 | doi = 10.3390/ijms14024242 | doi-access = free }}</ref> Another system for [[microRNA]] delivery under preliminary research is [[nanoparticles]] formed by the self-assembly of two different microRNAs to possibly shrink [[Neoplasm|tumors]].<ref>{{cite journal | vauthors = Conde J, Oliva N, Atilano M, Song HS, Artzi N | title = Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment | journal = Nature Materials | volume = 15 | issue = 3 | pages = 353β63 | date = March 2016 | pmid = 26641016 | pmc = 6594154 | doi = 10.1038/nmat4497 | bibcode = 2016NatMa..15..353C }}</ref> One potential application is based on small electromechanical systems, such as [[nanoelectromechanical system]]s being investigated for the active release of drugs and sensors for possible cancer treatment with iron nanoparticles or gold shells.<ref name="pubs.rsc.org">{{cite journal | vauthors = Juzgado A, SoldΓ A, Ostric A, Criado A, Valenti G, Rapino S, Conti G, Fracasso G, Paolucci F, Prato M | display-authors = 6 | title = Highly sensitive electrochemiluminescence detection of a prostate cancer biomarker | journal = Journal of Materials Chemistry B | volume = 5 | issue = 32 | pages = 6681β6687 | date = August 2017 | pmid = 32264431 | doi = 10.1039/c7tb01557g }}</ref> Another system of drug delivery involving nanoparticles is the use of [[Aquasome|aquasomes]], self-assembled nanoparticles with a [[Nanocrystalline material|nanocrystalline]] center, a coating made of a polyhydroxyl [[oligomer]], covered in the desired drug, which protects it from [[Dehydration reaction|dehydration]] and [[conformational change]].<ref name=":22">{{Cite journal |last1=Jagdale |first1=Sachin |last2=Karekar |first2=Simran |date=August 2020 |title=Bird's eye view on aquasome: Formulation and application |url=https://doi.org/10.1016/j.jddst.2020.101776 |journal=Journal of Drug Delivery Science and Technology |volume=58 |pages=101776 |doi=10.1016/j.jddst.2020.101776 |issn=1773-2247}}</ref>
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