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===Prodrome phase=== [[Prodromal]] or premonitory symptoms occur in about 60% of those with migraine,<ref name="Amin2009">{{cite book |title=Clinical neurology |vauthors=Simon RP, Aminoff MJ, Greenberg DA |publisher=Lange Medical Books/McGraw-Hill |year=2009 |isbn=9780071664332 |edition=7 |location=New York, N.Y |pages=85–88}}</ref><ref name=Five2004>{{cite book| vauthors = Lynn DJ, Newton HB, Rae-Grant A |title=The 5-minute neurology consult|year=2004|publisher=Lippincott Williams & Wilkins|location=Philadelphia|isbn=9780683307238|page=26|url=https://books.google.com/books?id=Atuv8-rVXRoC&pg=PA26|url-status=live|archive-url=https://web.archive.org/web/20170313021724/https://books.google.com/books?id=Atuv8-rVXRoC&pg=PA26|archive-date=13 March 2017}}</ref> with an onset that can range from two hours to two days before the start of pain or the aura.<ref name=Buzzi2005>{{cite journal | vauthors = Buzzi MG, Cologno D, Formisano R, Rossi P | title = Prodromes and the early phase of the migraine attack: therapeutic relevance | journal = Functional Neurology | volume = 20 | issue = 4 | pages = 179–83 | date = October–December 2005 | pmid = 16483458 }}</ref> These symptoms may include a wide variety of phenomena,<ref>{{cite journal | vauthors = Rossi P, Ambrosini A, Buzzi MG | title = Prodromes and predictors of migraine attack | journal = Functional Neurology | volume = 20 | issue = 4 | pages = 185–91 | date = October–December 2005 | pmid = 16483459 }}</ref> including altered mood, irritability, [[Depression (mood)|depression]] or [[euphoria (emotion)|euphoria]], [[fatigue (physical)|fatigue]], craving for certain food(s), stiff muscles (especially in the neck), constipation or [[diarrhea]], and sensitivity to smells or noise.<ref name=Five2004/> This may occur in those with either migraine with aura or migraine without aura.<ref name=Sam2009>{{cite book| vauthors = Ropper AH, Adams RD, Victor M, Samuels MA |title=Adams and Victor's principles of neurology|year=2009|publisher=McGraw-Hill Medical|location=New York|isbn=9780071499927|pages=Chapter 10|edition=9}}</ref> Neuroimaging indicates the [[limbic system]] and [[hypothalamus]] as the origin of prodromal symptoms in migraine.<ref>{{cite journal | vauthors = May A, Burstein R | title = Hypothalamic regulation of headache and migraine | journal = Cephalalgia | volume = 39 | issue = 13 | pages = 1710–1719 | date = November 2019 | pmid = 31466456 | pmc = 7164212 | doi = 10.1177/0333102419867280 }}</ref>
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