Editing Insulin-like growth factor (section)

==IGF receptors==
{{Main|Insulin-like growth factor receptor}}
The IGFs are known to bind the [[IGF-1 receptor]], the [[insulin receptor]], the [[insulin-like growth factor 2 receptor|IGF-2 receptor]], the insulin-related receptor and possibly other receptors.  The IGF-1 receptor is the "physiological" receptor. [[IGF-1]] binds to it at significantly higher affinity than it binds the insulin receptor.  Like the insulin receptor, the IGF-1 receptor is a [[receptor tyrosine kinase]]—meaning the receptor signals by causing the addition of a phosphate molecule on particular tyrosines. The IGF-2 receptor only binds IGF-2 and acts as a "clearance receptor"—it activates no intracellular signaling pathways, functioning only as an IGF-2 sequestering agent and preventing IGF-2 signaling.<ref>{{Cite journal |last1=Rosenzweig |first1=Steven A. |last2=Atreya |first2=Hanudatta S. |date=2010-10-15 |title=Defining the pathway to insulin-like growth factor system targeting in cancer |journal=Biochemical Pharmacology |volume=80 |issue=8 |pages=1115–1124 |doi=10.1016/j.bcp.2010.06.013 |issn=0006-2952 |pmc=2934757 |pmid=20599789}}</ref>