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== Causes == {{columns-list|colwidth=30em| Physical: * [[Burn (injury)|Burns]]<ref name="Hall">{{Cite book |title=Guyton and Hall textbook of medical physiology |vauthors=Hall J |date=2011 |publisher=Saunders/Elsevier |isbn=978-1-4160-4574-8 |edition=12th |location=Philadelphia, Pa. |page=428}}</ref> * [[Frostbite]] * [[Physical injury]], blunt or penetrating<ref>{{Cite book |url=https://www.ncbi.nlm.nih.gov/books/NBK53373/ |title=Inflammation and the Microcirculation |vauthors=Granger DN, Senchenkova E |date=2010 |publisher=Morgan & Claypool Life Sciences |series=Integrated Systems Physiology—From Cell to Function |volume=2 |pages=1–87 |chapter=Leukocyte–Endothelial Cell Adhesion |doi=10.4199/C00013ED1V01Y201006ISP008 |pmid=21452440 |access-date=1 July 2017 |chapter-url=https://www.ncbi.nlm.nih.gov/books/NBK53380/ |archive-url=https://web.archive.org/web/20210121004109/https://www.ncbi.nlm.nih.gov/books/NBK53373/ |archive-date=21 January 2021 |url-status=live}}</ref> * Foreign bodies, including [[splinters]], dirt and debris * Trauma<ref name=Hall/> * [[Ionizing radiation]] Biological: * Infection by [[pathogen]]s<ref name=Hall/> * Immune reactions due to [[hypersensitivity]] * Stress Chemical:<ref name=Hall/> * Chemical [[Irritation|irritants]] * [[Toxin]]s * Alcohol Psychological: * Excitement<ref>{{Cite journal |vauthors=Piira OP, Miettinen JA, Hautala AJ, Huikuri HV, Tulppo MP |date=October 2013 |title=Physiological responses to emotional excitement in healthy subjects and patients with coronary artery disease |journal=Autonomic Neuroscience |volume=177 |issue=2 |pages=280–5 |doi=10.1016/j.autneu.2013.06.001 |pmid=23916871 |s2cid=19823098}}</ref>}}
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