Editing Ibuprofen (section)

===Ibuprofen lysine===

In some countries, ibuprofen [[lysine]] (the lysine salt of ibuprofen, sometimes called "ibuprofen lysinate") is licensed for treatment of the same conditions as ibuprofen; the lysine salt is used because it is more water-soluble.<ref>{{cite journal | vauthors = Beaver WT | title = Review of the analgesic efficacy of ibuprofen | journal = International Journal of Clinical Practice. Supplement | issue = 135 | pages = 13–17 | date = April 2003 | pmid = 12723741 }}</ref> However, subsequent studies shown no statistical differences between the lysine salt and ibuprofen base.<ref>{{cite journal | vauthors = Kyselovič J, Koscova E, Lampert A, Weiser T | title = A Randomized, Double-Blind, Placebo-Controlled Trial of Ibuprofen Lysinate in Comparison to Ibuprofen Acid for Acute Postoperative Dental Pain | journal = Pain and Therapy | volume = 9 | issue = 1 | pages = 249–259 | date = June 2020 | pmid = 31912434 | pmc = 7203382 | doi = 10.1007/s40122-019-00148-1 }}</ref><ref>{{cite journal | vauthors = Moore AR, Derry S, Straube S, Ireson-Paine J, Wiffen PJ | title = Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain | journal = Pain | volume = 155 | issue = 1 | pages = 14–21 | date = January 2014 | pmid = 23969325 | doi = 10.1016/j.pain.2013.08.013 }}</ref>

In 2006, ibuprofen lysine was approved in the United States by the [[Food and Drug Administration]] (FDA) for closure of patent ductus arteriosus in premature infants weighing between {{cvt|500|and|1500|g|lb|0|abbr=on}}, who are no more than 32 weeks gestational age when usual medical management (such as fluid restriction, diuretics, and respiratory support) is not effective.<ref>{{cite journal | vauthors = Fanos V, Antonucci R, Zaffanello M | title = Ibuprofen and acute kidney injury in the newborn | journal = The Turkish Journal of Pediatrics | volume = 52 | issue = 3 | pages = 231–238 | year = 2010 | pmid = 20718179 }}</ref>