Editing Endometrium (section)

===Gene and protein expression===
{{Further |Bioinformatics#Gene and protein expression}}

About 20,000 protein coding genes are expressed in human cells and some 70% of these genes are expressed in the normal endometrium.<ref>{{Cite web|url=https://www.proteinatlas.org/humanproteome/endometrium|title=The human proteome in endometrium - The Human Protein Atlas|website=www.proteinatlas.org|access-date=2017-09-25}}</ref><ref>{{Cite journal|last1=Uhlén|first1=Mathias|last2=Fagerberg|first2=Linn|last3=Hallström|first3=Björn M.|last4=Lindskog|first4=Cecilia|last5=Oksvold|first5=Per|last6=Mardinoglu|first6=Adil|last7=Sivertsson|first7=Åsa|last8=Kampf|first8=Caroline|last9=Sjöstedt|first9=Evelina|date=2015-01-23|title=Tissue-based map of the human proteome|journal=Science|language=en|volume=347|issue=6220|pages=1260419|doi=10.1126/science.1260419|issn=0036-8075|pmid=25613900|s2cid=802377}}</ref> Just over 100 of these genes are more specifically expressed in the endometrium with only a handful genes being highly endometrium specific. The corresponding specific proteins are expressed in the glandular and stromal cells of the endometrial mucosa. The expression of many of these proteins vary depending on the menstrual cycle, for example the [[progesterone receptor]] and [[thyrotropin-releasing hormone]] both expressed in the proliferative phase, and [[PAEP]] expressed in the secretory phase. Other proteins such as the [[HOXA11|HOX11]] protein that is required for female fertility, is expressed in endometrial stroma cells throughout the menstrual cycle. Certain specific proteins such as the [[Estrogen receptor alpha|estrogen receptor]] are also expressed in other types of female tissue types, such as the [[cervix]], [[fallopian tube]]s, [[Ovary|ovaries]] and [[breast]].<ref>{{Cite journal|last1=Zieba|first1=Agata|last2=Sjöstedt|first2=Evelina|last3=Olovsson|first3=Matts|last4=Fagerberg|first4=Linn|last5=Hallström|first5=Björn M.|last6=Oskarsson|first6=Linda|last7=Edlund|first7=Karolina|last8=Tolf|first8=Anna|last9=Uhlen|first9=Mathias|date=2015-10-21|title=The Human Endometrium-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling|journal=OMICS: A Journal of Integrative Biology|volume=19|issue=11|pages=659–668|doi=10.1089/omi.2015.0115|pmid=26488136}}</ref>