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==Non-infective endocarditis== {{main|Noninfective endocarditis}} [[Nonbacterial thrombotic endocarditis]] (NBTE) is most commonly found on previously undamaged valves.<ref name=Robbins/> As opposed to infective endocarditis, the vegetations in NBTE are small, sterile, and tend to aggregate along the edges of the valve or the cusps.<ref name=Robbins/> Also unlike infective endocarditis, NBTE does not cause an inflammation response from the body.<ref name=Robbins/> NBTE usually occurs during a hypercoagulable state such as system-wide bacterial infection, or pregnancy, though it is also sometimes seen in patients with venous catheters.<ref name=Robbins/> NBTE may also occur in patients with cancer, particularly mucinous adenocarcinoma<ref name=Robbins/> where [[Trousseau syndrome]] can be encountered. Typically NBTE does not cause many problems on its own, but parts of the vegetations may break off and embolize to the heart or brain, or they may serve as a focus where bacteria can lodge, thus causing infective endocarditis.<ref name=Robbins/> Another form of sterile endocarditis is termed [[Libman–Sacks endocarditis]]; this form occurs more often in patients with [[lupus erythematosus]] and is thought to be due to the deposition of immune complexes.<ref name=Robbins/> Like NBTE, Libman-Sacks endocarditis involves small vegetations, while infective endocarditis is composed of large vegetations.<ref name=Robbins/> These immune complexes precipitate an inflammation reaction, which helps to differentiate it from NBTE. Also unlike NBTE, Libman-Sacks endocarditis does not seem to have a preferred location of deposition and may form on the undersurfaces of the valves or even on the endocardium.<ref name=Robbins/>
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