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== History == Catalase was first noticed in 1818 by [[Louis Jacques Thénard]], who discovered [[hydrogen peroxide]] (H<sub>2</sub>O<sub>2</sub>). Thénard suggested its breakdown was caused by an unknown substance. In 1900, [[Oscar Loew]] was the first to give it the name catalase, and found it in many plants and animals.<ref name="pmid17751716">{{cite journal | vauthors = Loew O | title = A New Enzyme of General Occurrence in Organisms | journal = Science | volume = 11 | issue = 279 | pages = 701–702 | date = May 1900 | pmid = 17751716 | doi = 10.1126/science.11.279.701 | bibcode = 1900Sci....11..701L | jstor = 1625707 | url = https://zenodo.org/record/1447826 }}</ref> In 1937 catalase from beef liver was crystallized by [[James B. Sumner]] and [[Alexander Dounce]]<ref name="pmid17776781">{{cite journal | vauthors = Sumner JB, Dounce AL | title = Crystalline Catalase | journal = Science | volume = 85 | issue = 2206 | pages = 366–367 | date = April 1937 | pmid = 17776781 | doi = 10.1126/science.85.2206.366 | bibcode = 1937Sci....85..366S }}</ref> and the molecular weight was measured in 1938.<ref name="pmid17831682">{{cite journal | vauthors = Sumner JB, Gralén N | title = The Molecular Weight of Crystalline Catalase | journal = Science | volume = 87 | issue = 2256 | pages = 284 | date = March 1938 | pmid = 17831682 | doi = 10.1126/science.87.2256.284 | bibcode = 1938Sci....87..284S | s2cid = 36931581 }}</ref> The [[amino acid]] sequence of [[bovine]] catalase was determined in 1969,<ref name="pmid4892021">{{cite journal | vauthors = Schroeder WA, Shelton JR, Shelton JB, Robberson B, Apell G | title = The amino acid sequence of bovine liver catalase: a preliminary report | journal = Archives of Biochemistry and Biophysics | volume = 131 | issue = 2 | pages = 653–655 | date = May 1969 | pmid = 4892021 | doi = 10.1016/0003-9861(69)90441-X }}</ref> and the three-dimensional structure in 1981.<ref name="pmid7328661">{{cite journal | vauthors = Murthy MR, Reid TJ, Sicignano A, Tanaka N, Rossmann MG | title = Structure of beef liver catalase | journal = Journal of Molecular Biology | volume = 152 | issue = 2 | pages = 465–499 | date = October 1981 | pmid = 7328661 | doi = 10.1016/0022-2836(81)90254-0 }}</ref>
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