Editing Calreticulin (section)

=== Transcription regulation ===

Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the [[synthetic peptide]] KLGFFKR, which is almost identical to an amino acid sequence in the [[DNA-binding domain]] of the superfamily of [[nuclear receptor]]s. The [[N-terminus|amino terminus]] of calreticulin interacts with the DNA-binding domain of the [[glucocorticoid receptor]] and prevents the receptor from binding to its specific [[glucocorticoid response element]]. Calreticulin can inhibit the binding of [[androgen receptor]] to its hormone-responsive DNA element and can inhibit androgen receptor and [[retinoic acid receptor]] transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.