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Bornholm disease
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==Etiology== Inoculation of throat washings taken from people with this disease into the brains of newborn mice revealed that [[enterovirus]]es in the [[Coxsackie B virus]] group were likely to be the cause of pleurodynia,<ref name="pmid14774516">{{cite journal |last1= Weller |first1= TH |last2= Enders |first2= JF |last3= Buckingham |first3= M |last4= Finn |first4= JJ |title=The etiology of epidemic pleurodynia: a study of two viruses isolated from a typical outbreak |journal=J. Immunol. |volume=65 |issue=3 |pages=337β46 |date=September 1950 |doi= 10.4049/jimmunol.65.3.337 |pmid=14774516 |s2cid= 32388798 |url=http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=14774516|doi-access= free }}</ref> and those findings were supported by subsequent studies of [[Immunoglobulin M|IgM]] antibody responses measured in [[Serum (blood)|serum]] from people with pleurodynia.<ref name="pmid4199715">{{cite journal |vauthors=Schmidt NJ, Magoffin RL, Lennette EH |title=Association of group B coxsackie viruses with cases of pericarditis, myocarditis, or pleurodynia by demonstration of immunoglobulin M antibody |journal=Infect. Immun. |volume=8 |issue=3 |pages=341β8 |date=September 1973 |doi=10.1128/iai.8.3.341-348.1973 |pmid=4199715 |pmc=422854 |url=}}</ref> Other viruses in the enterovirus family, including [[echovirus]] and [[Coxsackie A virus]], are less frequently associated with pleurodynia.<ref name="pmid5581711">{{cite journal |vauthors=Bell EJ, Grist NR |title=ECHO viruses, carditis, and acute pleurodynia |journal=Am. Heart J. |volume=82 |issue=1 |pages=133β5 |date=July 1971 |pmid=5581711 |doi= 10.1016/0002-8703(71)90173-6}}</ref> Echovirus types 1,6,8,9, and 19 and Coxsackie A virus types 4,6,9, and 10 are associated with Bornholm disease. The most common strains causing Bornholm disease are Coxsackie B3 and A9. Viral proliferation in the muscles of the chest wall, diaphragm, and abdomen are thought to contribute to the typical presentation that characterizes the illness.<ref name="Respiratory Medicine Case Reports">{{cite journal |last1=Lal |first1=Amos |last2=Akhtar |first2=Jamal |last3=Isaac |first3=Sangeetha |last4=Mishra |first4=Ajay |last5=Khan |first5=Mohammad |last6=Noreldin |first6=Mohsen |last7=Abraham |first7=George |title=Unusual cause of chest pain, Bornholm Disease, a forgotten entity; case report and review of literature |journal=Respiratory Medicine Case Reports |year=2018 |volume=25 |pages=270β273 |publisher=ELSEVIER |doi=10.1016/j.rmcr.2018.10.005 |pmid=30364740 |pmc=6197799 }}</ref>
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