Editing Biotin (section)

==Dietary recommendations==
The US National Academy of Medicine updated [[Dietary Reference Intake]]s for many vitamins in 1998. At that time there was insufficient information to establish estimated average requirement or recommended dietary allowance, terms that exist for most vitamins. In instances such as this, the academy sets adequate intakes (AIs) with the understanding that at some later date, when the [[physiology|physiological]] effects of biotin are better understood, AIs will be replaced by more exact information. The biotin AIs for both males and females are: 
{| class="wikitable"
|+ Biotin Adequate Intakes (AIs)<ref name="DRItext">{{cite book | last1 = Institute of Medicine | title = Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline | chapter = Biotin | publisher = The National Academies Press | year = 1998 | location = Washington, DC | pages = 374–89 | chapter-url = http://www.nap.edu/openbook.php?record_id=6015&page=374 | access-date = 2017-08-29 | isbn = 0-309-06554-2 | author1-link = Institute of Medicine | archive-date = July 17, 2015 | archive-url = https://web.archive.org/web/20150717032607/http://www.nap.edu/openbook.php?record_id=6015&page=374 | url-status = live }}</ref>
|-
! Age Group !! Biotin AI (μg/day)
|-
| 0 to 6 months || 5
|-
| 7 to 12 months || 6
|-
| 1 to 3 years || 8
|-
| 4 to 8 years || 12
|-
| 9 to 13 years || 20
|-
| 14 to 18 years || 25
|-
| 19 years and older || 30
|-
| Pregnant females (14 to 50 years) || 30
|-
| Lactating females (14 to 50 years) || 35
|}

Australia and New Zealand set AIs similar to the US.<ref name=AustNZ>{{cite web |url=http://www.nhmrc.gov.au/_files_nhmrc/file/publications/synopses/n35.pdf |title=National Health and Medical Research Council: Nutrient Reference Values for Australia and New Zealand |access-date=2010-02-19 |archive-url=https://web.archive.org/web/20170121003340/https://www.nhmrc.gov.au/_files_nhmrc/file/publications/synopses/n35.pdf |archive-date=2017-01-21 |url-status=dead }}</ref>

The [[European Food Safety Authority]] (EFSA) also identifies AIs, setting values at 40&nbsp;μg/day for adults, pregnancy at 40&nbsp;μg/day, and breastfeeding at 45&nbsp;μg/day. For children ages 1–17 years, the AIs increase with age from 20 to 35&nbsp;μg/day.<ref name=EFSA2017>{{cite web| title = Overview on Dietary Reference Values for the EU population as derived by the EFSA Panel on Dietetic Products, Nutrition and Allergies| year = 2017| url = https://www.efsa.europa.eu/sites/default/files/assets/DRV_Summary_tables_jan_17.pdf| access-date = August 30, 2017| archive-date = August 28, 2017| archive-url = https://web.archive.org/web/20170828082247/https://www.efsa.europa.eu/sites/default/files/assets/DRV_Summary_tables_jan_17.pdf| url-status = live}}</ref>

===Safety===
The US National Academy of Medicine estimates upper limits for vitamins and minerals when evidence for a true limit is sufficient. For biotin, however, there is no upper limit because the adverse effects of high biotin intake have not been determined.<ref name="DRItext" /> The EFSA also reviewed safety and reached the same conclusion as in the United States.<ref>{{cite web| title = Tolerable Upper Intake Levels For Vitamins And Minerals| publisher = European Food Safety Authority| year = 2006| url = http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf| access-date = March 4, 2016| archive-date = March 16, 2016| archive-url = https://web.archive.org/web/20160316225123/http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf| url-status = live}}</ref>

===Labeling regulations===
For US food and dietary supplement labeling purposes, the amount in a serving is expressed as a percent of daily value. For biotin labeling purposes, 100% of the daily value was 300&nbsp;μg/day, but as of May 27, 2016, it was revised to 30&nbsp;μg/day to agree with the adequate intake.<ref name="FedReg">{{cite web|url=https://www.gpo.gov/fdsys/pkg/FR-2016-05-27/pdf/2016-11867.pdf|title=Federal Register May 27, 2016 Food Labeling: Revision of the Nutrition and Supplement Facts Labels |archive-url=https://web.archive.org/web/20170922104400/https://www.gpo.gov/fdsys/pkg/FR-2016-05-27/pdf/2016-11867.pdf|archive-date=2017-09-22|url-status=live}}</ref><ref>{{cite web | title=Daily Value Reference of the Dietary Supplement Label Database (DSLD) | website=Dietary Supplement Label Database (DSLD) | url=https://www.dsld.nlm.nih.gov/dsld/dailyvalue.jsp | access-date=16 May 2020 | archive-date=7 April 2020 | archive-url=https://web.archive.org/web/20200407073956/https://dsld.nlm.nih.gov/dsld/dailyvalue.jsp | url-status=dead }}</ref> Compliance with the updated labeling regulations was required by January 1, 2020, for manufacturers with [[US$]]10&nbsp;million or more in annual food sales, and by January 1, 2021, for manufacturers with lower volume food sales.<ref name="FDAdelay">{{cite web | title=Changes to the Nutrition Facts Label | website=U.S. [[Food and Drug Administration]] (FDA) | date=27 May 2016 | url=https://www.fda.gov/food/food-labeling-nutrition/changes-nutrition-facts-label | access-date=16 May 2020 | archive-date=May 6, 2018 | archive-url=https://web.archive.org/web/20180506080421/https://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/LabelingNutrition/ucm385663.htm | url-status=live }} {{PD-notice}}</ref><ref>{{cite web | title=Industry Resources on the Changes to the Nutrition Facts Label | website=U.S. [[Food and Drug Administration]] (FDA) | date=21 December 2018 | url=https://www.fda.gov/food/food-labeling-nutrition/industry-resources-changes-nutrition-facts-label | access-date=16 May 2020 | archive-date=December 25, 2020 | archive-url=https://web.archive.org/web/20201225063145/https://www.fda.gov/food/food-labeling-nutrition/industry-resources-changes-nutrition-facts-label | url-status=live }} {{PD-notice}}</ref> A table of the old and new adult daily values is provided at [[Reference Daily Intake]].