Editing Zeolite (section)

=== Hemostatic agent ===

The original formulation of [[QuikClot]] brand [[Hemostatic agents|hemostatic agent]], which is used to stop severe bleeding,<ref>{{Cite journal|display-authors=3|vauthors=Rhee P, Brown C, Martin M, Salim A, Plurad D, Green D, Chambers L, Demetriades D, Velmahos G, Alam H|year=2008|title=QuikClot use in trauma for hemorrhage control: case series of 103 documented uses|journal=The Journal of Trauma and Acute Care Surgery|volume=64|issue=4|pages=1093–9|doi=10.1097/TA.0b013e31812f6dbc|pmid=18404080|s2cid=24827908}}</ref> contained zeolite granules. When in contact with blood, the granules would rapidly absorb water from the blood plasma, creating an exothermic reaction which generated heat. The absorption of water would also concentrate clotting factors present within the blood, causing the clot formation process to occur much faster than under normal circumstances, as shown [[in vitro]].<ref>{{Cite journal|display-authors=3 |last1=Li |first1=Jing |last2=Cao |first2=Wei |last3=Lv |first3=Xiao-xing |last4=Jiang |first4=Li |last5=Li |first5=Yue-jun |last6=Li |first6=Wang-zhou |last7=Chen |first7=Shao-zong |last8=Li |first8=Xue-yong |date=2013-03-01 |title=Zeolite-based hemostat QuikClot releases calcium into blood and promotes blood coagulation in vitro |journal=Acta Pharmacologica Sinica |volume=34 |issue=3 |pages=367–372 |doi=10.1038/aps.2012.159 |issn=1671-4083 |pmc=4002488 |pmid=23334236}}</ref>

The 2022 formulation of QuikClot uses a nonwoven material impregnated with [[Kaolinite|kaolin]], an inorganic mineral activating [[Factor XII]], in turn accelerating natural clotting.<ref>{{Cite web |title=QuikClot for Military {{!}} US Dept of Defense Hemostatic Dressing of Choice |url=https://quikclot.com/EN/Products/Military|date=2022 |access-date=2023-10-01 |publisher=Teleflex Inc.}}</ref> Unlike the original zeolite formulation, [[Kaolinite|kaolin]] does not exhibit any thermogenic properties.