Editing Zebrafish (section)

====Genome sequencing====
The [[Wellcome Trust Sanger Institute]] started the zebrafish genome sequencing project in 2001, and the full genome sequence of the Tuebingen reference strain is publicly available at the [[National Center for Biotechnology Information]] (NCBI)'s [https://www.ncbi.nlm.nih.gov/genome?term=danio%20rerio Zebrafish Genome Page]. The zebrafish reference genome sequence is annotated as part of the [[Ensembl]] [http://www.ensembl.org/Danio_rerio/Info/Index project], and is maintained by the [[Genome Reference Consortium]].<ref>{{cite web |title=Genome Reference Consortium |url=https://www.ncbi.nlm.nih.gov/projects/genome/assembly/grc/ |publisher=GRC |access-date=October 23, 2012 |archive-date=October 5, 2016 |archive-url=https://web.archive.org/web/20161005062544/https://www.ncbi.nlm.nih.gov/projects/genome/assembly/grc/ |url-status=live}}</ref>

In 2009, researchers at the [[Institute of Genomics and Integrative Biology]] in Delhi, India, announced the sequencing of the genome of a wild zebrafish strain, containing an estimated 1.7 billion genetic letters.<ref>[http://www.indianexpress.com/news/Decoding-the-Genome-Mystery/485122 "Decoding the Genome Mystery"] {{Webarchive|url=https://web.archive.org/web/20090715190646/http://www.indianexpress.com/news/Decoding-the-Genome-Mystery/485122 |date=2009-07-15 }}. ''[[Indian Express]]''. July 5, 2009. Retrieved February 5, 2013.</ref><ref>[http://genome.igib.res.in/ FishMap Zv8] {{Webarchive|url=https://web.archive.org/web/20180719084933/http://genome.igib.res.in/ |date=2018-07-19 }}. [[Institute of Genomics and Integrative Biology]] (IGIB). Retrieved June 7, 2012.</ref> The genome of the wild zebrafish was sequenced at 39-fold coverage. Comparative analysis with the zebrafish reference genome revealed over 5 million single nucleotide variations and over 1.6 million insertion deletion variations. The zebrafish reference genome sequence of 1.4GB and over 26,000 protein coding genes was published by Kerstin Howe ''et al.'' in 2013.<ref name=howe2013>{{cite journal |vauthors=Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett JC, Koch R, Rauch GJ, White S, Chow W, Kilian B, Quintais LT, Guerra-Assunção JA, Zhou Y, Gu Y, Yen J, Vogel JH, Eyre T, Redmond S, Banerjee R, Chi J, Fu B, Langley E, Maguire SF, Laird GK, Lloyd D, Kenyon E, Donaldson S, Sehra H, Almeida-King J, Loveland J, Trevanion S, Jones M, Quail M, Willey D, Hunt A, Burton J, Sims S, McLay K, Plumb B, Davis J, Clee C, Oliver K, Clark R, Riddle C, Elliot D, Eliott D, Threadgold G, Harden G, Ware D, Begum S, Mortimore B, Mortimer B, Kerry G, Heath P, Phillimore B, Tracey A, Corby N, Dunn M, Johnson C, Wood J, Clark S, Pelan S, Griffiths G, Smith M, Glithero R, Howden P, Barker N, Lloyd C, Stevens C, Harley J, Holt K, Panagiotidis G, Lovell J, Beasley H, Henderson C, Gordon D, Auger K, Wright D, Collins J, Raisen C, Dyer L, Leung K, Robertson L, Ambridge K, Leongamornlert D, McGuire S, Gilderthorp R, Griffiths C, Manthravadi D, Nichol S, Barker G, Whitehead S, Kay M, Brown J, Murnane C, Gray E, Humphries M, Sycamore N, Barker D, Saunders D, Wallis J, Babbage A, Hammond S, Mashreghi-Mohammadi M, Barr L, Martin S, Wray P, Ellington A, Matthews N, Ellwood M, Woodmansey R, Clark G, Cooper J, Cooper J, Tromans A, Grafham D, Skuce C, Pandian R, Andrews R, Harrison E, Kimberley A, Garnett J, Fosker N, Hall R, Garner P, Kelly D, Bird C, Palmer S, Gehring I, Berger A, Dooley CM, Ersan-Ürün Z, Eser C, Geiger H, Geisler M, Karotki L, Kirn A, Konantz J, Konantz M, Oberländer M, Rudolph-Geiger S, Teucke M, Lanz C, Raddatz G, Osoegawa K, Zhu B, Rapp A, Widaa S, Langford C, Yang F, Schuster SC, Carter NP, Harrow J, Ning Z, Herrero J, Searle SM, Enright A, Geisler R, Plasterk RH, Lee C, Westerfield M, de Jong PJ, Zon LI, Postlethwait JH, Nüsslein-Volhard C, Hubbard TJ, Roest Crollius H, Rogers J, Stemple DL |display-authors=6 |title=The zebrafish reference genome sequence and its relationship to the human genome |journal=[[Nature (journal)|Nature]] |volume=496 |issue=7446 |pages=498–503 |date=April 2013 |pmid=23594743 |pmc=3703927 |doi=10.1038/nature12111 |bibcode=2013Natur.496..498H}}</ref>