Jump to content
Main menu
Main menu
move to sidebar
hide
Navigation
Main page
Recent changes
Random page
Help about MediaWiki
Special pages
Niidae Wiki
Search
Search
Appearance
Create account
Log in
Personal tools
Create account
Log in
Pages for logged out editors
learn more
Contributions
Talk
Editing
Vancomycin
(section)
Page
Discussion
English
Read
Edit
View history
Tools
Tools
move to sidebar
hide
Actions
Read
Edit
View history
General
What links here
Related changes
Page information
Appearance
move to sidebar
hide
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==Total synthesis== Both the vancomycin [[aglycone]]<ref name="pmid29711601">{{cite journal | vauthors = Evans DA, Wood MR, Trotter BW, Richardson TI, Barrow JC, Katz JL | title = Total Syntheses of Vancomycin and Eremomycin Aglycons | journal = Angewandte Chemie | volume = 37 | issue = 19 | pages = 2700β2704 | date = October 1998 | pmid = 29711601 | doi = 10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P | doi-access = free | title-link = doi }}</ref><ref name="Herzner-2008">{{cite book |title= Organic Synthesis Highlights |volume= IV |pages= 281β288 | veditors = Schmalz HG |year= 2008 |publisher= John Wiley & Sons |chapter= 38. Crossing the Finishing Line: Total Syntheses of the Vancomycin Aglycon | vauthors = Herzner H, RΓΌck-Braun K |doi= 10.1002/9783527619979.ch38 |isbn= 978-3-527-61997-9 }}</ref> and the complete vancomycin molecule<ref name="Nicolaou-1999">{{cite journal | vauthors = Nicolaou KC, Mitchell HJ, Jain NF, Winssinger N, Hughes R, Bando T | year = 1999 | title = Total Synthesis of Vancomycin | journal = Angew. Chem. Int. Ed. | volume = 38 | issue = 1β2| pages = 240β244 | doi = 10.1002/(SICI)1521-3773(19990115)38:1/2<240::AID-ANIE240>3.0.CO;2-5 }}</ref> have been targets successfully reached by [[total synthesis]]. The target was first achieved by David Evans in October 1998, KC Nicolaou in December 1998, Dale Boger in 1999, and more selectively synthesized again by Boger in 2020.<ref name="pmid29711601" /><ref name="pmid29375134">{{cite journal | vauthors = Winssinger N | title = Biography of Professor Nicolaou: a journey to the extremes of molecular complexity | journal = The Journal of Antibiotics | volume = 71 | issue = 2 | pages = 149β150 | date = February 2018 | pmid = 29375134 | doi = 10.1038/ja.2017.144 | doi-access = free | title-link = doi | department = Editorial }}</ref><ref name="pmid32885969">{{Cite journal |url=https://doi.org/10.1021/jacs.0c07433.s001 |title=Next-Generation Total Synthesis of Vancomycin | vauthors = Moore MJ, Qu S, Tan C, Cai Y, Mogi Y, Keith DJ, Boger DL | journal = J. Am. Chem. Soc. | year = 202 | volume = 142 | issue = 37 | pages = 16039β16050 | doi = 10.1021/jacs.0c07433 |pmid=32885969 |access-date=13 July 2024 |archive-date=13 July 2024 |archive-url=https://web.archive.org/web/20240713122125/https://doi.org/10.1021/jacs.0c07433.s001 |url-status=live | format = PDF | pmc = 7501256 }}</ref>
Summary:
Please note that all contributions to Niidae Wiki may be edited, altered, or removed by other contributors. If you do not want your writing to be edited mercilessly, then do not submit it here.
You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource (see
Encyclopedia:Copyrights
for details).
Do not submit copyrighted work without permission!
Cancel
Editing help
(opens in new window)
Search
Search
Editing
Vancomycin
(section)
Add topic