Jump to content
Main menu
Main menu
move to sidebar
hide
Navigation
Main page
Recent changes
Random page
Help about MediaWiki
Special pages
Niidae Wiki
Search
Search
Appearance
Create account
Log in
Personal tools
Create account
Log in
Pages for logged out editors
learn more
Contributions
Talk
Editing
Scorpion
(section)
Page
Discussion
English
Read
Edit
View history
Tools
Tools
move to sidebar
hide
Actions
Read
Edit
View history
General
What links here
Related changes
Page information
Appearance
move to sidebar
hide
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
===Potential medical use=== [[File:Chlorotoxin.png|thumb|upright|The [[deathstalker]]'s powerful venom contains the 36-[[amino acid]] peptide [[chlorotoxin]] ([[ribbon diagram]] shown). This blocks small-conductance [[chloride channel]]s, immobilizing its prey.<ref name="Ahmadi Knerr Argemi Bordon p=118"/>]] Scorpion venom is a mixture of neurotoxins; most of these are [[peptide]]s, chains of [[amino acid]]s.<ref name="Rodríguez 2013">{{cite book |last1=Rodríguez de la Vega |first1=Ricardo C. |last2=Vidal |first2=Nicolas |last3=Possani |first3=Lourival D. |chapter=Scorpion Peptides |editor-first=Abba J. |editor-last=Kastin |title=Handbook of Biologically Active Peptides |publisher=Academic Press |edition=2nd |year=2013 |isbn=978-0-12-385095-9 |pages=423–429 |doi=10.1016/B978-0-12-385095-9.00059-2}}</ref> Many of them interfere with [[membrane channel]]s that [[Sodium channel|transport sodium]], [[Potassium channel|potassium]], [[calcium channel|calcium]], or [[Chloride channel|chloride]] ions. These channels are essential for [[nerve conduction]], [[muscle contraction]] and many other biological processes. Some of these molecules may be useful in medical research and might lead to the development of new disease treatments. Among their potential therapeutic uses are as analgesic, [[anti-cancer]], [[antibacterial]], [[antifungal]], [[antiviral]], [[antiparasitic]], [[bradykinin]]-potentiating, and [[immunosuppressive]] drugs. As of 2020, no scorpion toxin-based drug is for sale, though [[chlorotoxin]] is being trialled for use against [[glioma]], a brain cancer.<ref name="Ahmadi Knerr Argemi Bordon p=118">{{cite journal |last1=Ahmadi |first1=Shirin |last2=Knerr |first2=Julius M. |last3=Argemi |first3=Lídia |last4=Bordon |first4=Karla C. F. |last5=Pucca |first5=Manuela B. |last6=Cerni |first6=Felipe A. |last7=Arantes |first7=Eliane C. |last8=Çalışkan |first8=Figen |last9=Laustsen |first9=Andreas H. |title=Scorpion Venom: Detriments and Benefits |journal=Biomedicines |publisher=MDPI AG |volume=8 |issue=5 |date=12 May 2020 |issn=2227-9059 |doi=10.3390/biomedicines8050118 |pmid=32408604 |pmc=7277529 |page=118|doi-access=free }}</ref>
Summary:
Please note that all contributions to Niidae Wiki may be edited, altered, or removed by other contributors. If you do not want your writing to be edited mercilessly, then do not submit it here.
You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource (see
Encyclopedia:Copyrights
for details).
Do not submit copyrighted work without permission!
Cancel
Editing help
(opens in new window)
Search
Search
Editing
Scorpion
(section)
Add topic