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=== Antibiotic resistance === {{Main|Antibiotic resistance}} Antibiotic-resistant microorganisms, which sometimes are referred to as "[[Antibiotic resistance|superbug]]s", may contribute to the re-emergence of diseases with pandemic potential that are currently well controlled.<ref>{{cite web | url = http://www.pasteur.fr/actu/presse/press/07pesteTIGR_E.htm | title = Researchers sound the alarm: the multidrug resistance of the plague bacillus could spread | archive-url = https://web.archive.org/web/20071014012153/http://www.pasteur.fr/actu/presse/press/07pesteTIGR_E.htm| archive-date = 14 October 2007 | work = Pasteur.fr }}</ref> For example, cases of tuberculosis that are resistant to traditionally effective treatments remain a cause of great concern to health professionals. Every year, nearly half a million new cases of [[multidrug-resistant tuberculosis]] (MDR-TB) are estimated to occur worldwide.<ref>[https://web.archive.org/web/20090406170131/http://www.who.int/mediacentre/news/releases/2009/tuberculosis_drug_resistant_20090402/en/index.html Health ministers to accelerate efforts against drug-resistant TB]. ''World Health Organization.''</ref> China and India have the highest rate of MDR-TB.<ref>[https://www.theguardian.com/society/2009/apr/01/bill-gates-tb-timebomb-china Bill Gates joins Chinese government in tackling TB 'timebomb']. ''Guardian.co.uk''. 1 April 2009</ref> WHO reports that approximately 50 million people worldwide are infected with MDR-TB, with 79 percent of those cases resistant to three or more antibiotics. Extensively drug-resistant tuberculosis ([[XDR TB|XDR-TB]]) was first identified in Africa in 2006 and subsequently discovered to exist in 49 countries. During 2021 there were estimated to be around 25,000 cases XDR-TB worldwide.<ref>{{cite web |title=Global Tuberculosis Report |url=https://www.who.int/teams/global-tuberculosis-programme/tb-reports |access-date=30 June 2023 |website=World Health Organization }}</ref> In the past 20 years, other common bacteria including ''[[Staphylococcus aureus]]'', ''[[Serratia marcescens]]'' and ''[[Enterococcus]]'', have developed resistance to a wide range of [[antibiotics]]. Antibiotic-resistant organisms have become an important cause of healthcare-associated ([[Hospital-acquired infection|nosocomial]]) infections.<ref name=":8">{{cite journal |vauthors=Murray CJ, Ikuta KS, Sharara F, Swetschinski L, Aguilar GR, Gray A, etal |date=February 2022 |title=Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis |journal=Lancet |volume=399 |issue=10325 |pages=629β655 |doi=10.1016/S0140-6736(21)02724-0 |pmc=8841637 |pmid=35065702 |s2cid=246077406 |collaboration=Antimicrobial Resistance Collaborators}}</ref>
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