Editing G protein-coupled receptor (section)

===cAMP signal pathway===

{{Main|cAMP-dependent pathway}}
The cAMP signal transduction contains five main characters: stimulative [[hormone]] receptor (Rs) or inhibitory [[hormone receptor]] (Ri); stimulative regulative G-protein (Gs) or inhibitory regulative G-protein (Gi); [[adenylyl cyclase]]; [[protein kinase A|protein kinase&nbsp;A]] (PKA); and cAMP [[phosphodiesterase]].

Stimulative hormone receptor (Rs) is a receptor that can bind with stimulative signal molecules, while inhibitory hormone receptor (Ri) is a receptor that can bind with inhibitory signal molecules.

Stimulative regulative G-protein is a G-protein linked to stimulative hormone receptor (Rs), and its α subunit upon activation could stimulate the activity of an enzyme or other intracellular metabolism. On the contrary, inhibitory regulative G-protein is linked to an inhibitory hormone receptor, and its α subunit upon activation could inhibit the activity of an enzyme or other intracellular metabolism.

Adenylyl cyclase is a 12-transmembrane glycoprotein that catalyzes the conversion of ATP to cAMP with the help of cofactor Mg<sup>2+</sup> or Mn<sup>2+</sup>. The cAMP produced is a second messenger in cellular metabolism and is an allosteric activator of protein kinase A.

Protein kinase&nbsp;A is an important enzyme in cell metabolism due to its ability to regulate cell metabolism by phosphorylating specific committed enzymes in the metabolic pathway. It can also regulate specific gene expression, cellular secretion, and membrane permeability. The protein enzyme contains two catalytic subunits and two regulatory subunits. When there is no cAMP, the complex is inactive. When cAMP binds to the regulatory subunits, their conformation is altered, causing the dissociation of the regulatory subunits, which activates protein kinase A and allows further biological effects.

These signals then can be terminated by cAMP phosphodiesterase, which is an enzyme that degrades cAMP to 5'-AMP and inactivates protein kinase&nbsp;A.