Editing Dengue fever (section)

== Research ==
Research directions include dengue [[pathogenesis]] (the process by which the disease develops in humans), as well as the  biology, ecology and behaviour of the mosquito vector. Improved [[Diagnosis|diagnostics]] would enable faster and more appropriate treatment.<ref>{{cite journal | vauthors = Laughlin CA, Morens DM, Cassetti MC, Costero-Saint Denis A, San Martin JL, Whitehead SS, Fauci AS | title = Dengue research opportunities in the Americas | journal = The Journal of Infectious Diseases | volume = 206 | issue = 7 | pages = 1121–1127 | date = October 2012 | pmid = 22782946 | pmc = 3499110 | doi = 10.1093/infdis/jis351 }}</ref> Attempts are ongoing to develop an [[Antiviral drug|antiviral]] medicine targeting the NS3 or NS5 proteins.<ref>{{cite journal | vauthors = Obi JO, Gutiérrez-Barbosa H, Chua JV, Deredge DJ | title = Current Trends and Limitations in Dengue Antiviral Research | journal = Tropical Medicine and Infectious Disease | volume = 6 | issue = 4 | pages = 180 | date = September 2021 | pmid = 34698303 | pmc = 8544673 | doi = 10.3390/tropicalmed6040180 | doi-access = free }}</ref>

In addition to the two vaccines which are already available, several vaccine candidates are in development.<ref>{{cite journal | vauthors = Kariyawasam R, Lachman M, Mansuri S, Chakrabarti S, Boggild AK | title = A dengue vaccine whirlwind update | journal = Therapeutic Advances in Infectious Disease | volume = 10 | pages = 20499361231167274 | date = 2023-04-20 | pmid = 37114191 | pmc = 10126642 | doi = 10.1177/20499361231167274 }}</ref>

An area of active research is developing experimental models for Dengue, beyond experimental animal models. [[organ-on-a-chip|Organ Chips]] and Lab-on-Chips have been developed to model Dengue leak syndrome and [[mechanobiology|mechanopathology]].<ref>{{cite web |last1=LBSP |first1=Bilyana |title=Leiden scientists create first-ever dengue-on-a-chip to study this deadly virus |url=https://leidenbiosciencepark.nl/news/leiden-scientists-create-first-ever-dengue-on-a-chip-to-study-this-deadly-virus/ |website=Leiden Bio Science Park |date=11 April 2025}}</ref><ref>{{cite journal |last1=Tang |first1=Huaqi |last2=Evers |first2=Tom M. J. |last3=Babaei |first3=Mehrad |last4=Mashaghi |first4=Alireza |title=Revealing Mechanopathology Induced by Dengue NS1 Using Organ Chips and Single-Cell Force Spectroscopy |journal=ACS Biomaterials Science & Engineering |date=14 April 2025 |volume=11 |issue=4 |pages=2448–2455 |doi=10.1021/acsbiomaterials.4c02410|pmc=12001184 }}</ref>