Editing DNA replication (section)

== Problems with DNA replication ==
{{Main|DNA replication stress}}
{{Expand section|date=May 2020}}
[[File:Replication fork restarts by homologous recombination following replication stress.png|thumb|left|Replication fork restarts by homologous recombination following replication stress]]
[[File:Epigenetic consequences of nucleosome reassembly defects at stalled replication forks.png|thumb|Epigenetic consequences of nucleosome reassembly defects at stalled replication forks]]

There are many events that contribute to replication stress, including:<ref>{{Cite journal |vauthors=Zeman MK, Cimprich KA |date=January 2014 |title=Causes and consequences of replication stress |journal=Nature Cell Biology |volume=16 |issue=1 |pages=2–9 |doi=10.1038/ncb2897 |pmc=4354890 |pmid=24366029}}</ref>
* Misincorporation of ribonucleotides
* Unusual [[Nucleic acid secondary structure|DNA structures]]
* Conflicts between replication and transcription
* Insufficiency of essential replication factors
* [[Chromosomal fragile site|Common fragile sites]]
* Overexpression or constitutive activation of [[oncogene]]s
* [[Chromatin]] inaccessibility