Editing Clozapine (section)

===Withdrawal effects===
Abrupt withdrawal may lead to [[cholinergic]] [[rebound effects]], such as indigestion, diarrhea, nausea/vomiting, overabundance of saliva, profuse sweating, insomnia, and agitation.<ref>{{cite journal | vauthors = Stevenson E, Schembri F, Green DM, Burns JD | title = Serotonin syndrome associated with clozapine withdrawal | journal = JAMA Neurology | volume = 70 | issue = 8 | pages = 1054–1055 | date = August 2013 | pmid = 23753931 | doi = 10.1001/jamaneurol.2013.95 | doi-access = free }}</ref> Abrupt withdrawal can also cause severe movement disorders, catatonia, and psychosis.<ref>{{cite journal | vauthors = Wadekar M, Syed S | title = Clozapine-withdrawal catatonia | journal = Psychosomatics | volume = 51 | issue = 4 | pages = 355–355.e2 | date = July 2010 | pmid = 20587767 | doi = 10.1176/appi.psy.51.4.355 }}</ref> Doctors have recommended that patients, families, and caregivers be made aware of the symptoms and risks of abrupt withdrawal of clozapine. When discontinuing clozapine, gradual dose reduction is recommended to reduce the intensity of withdrawal effects.<ref name="Ahmed-1998">{{cite journal | vauthors = Ahmed S, Chengappa KN, Naidu VR, Baker RW, Parepally H, Schooler NR | title = Clozapine withdrawal-emergent dystonias and dyskinesias: a case series | journal = The Journal of Clinical Psychiatry | volume = 59 | issue = 9 | pages = 472–477 | date = September 1998 | pmid = 9771818 | doi = 10.4088/JCP.v59n0906 }}</ref><ref name="Szafrański-">{{cite journal | vauthors = Szafrański T, Gmurkowski K | title = [Clozapine withdrawal. A review] | journal = Psychiatria Polska | volume = 33 | issue = 1 | pages = 51–67 | year = 1999 | pmid = 10786215 }}</ref>