Editing Cerebellum (section)

===Aging===
The human cerebellum changes with age. These changes may differ from those of other parts of the brain.
The cerebellum is the youngest brain region (and body part) in centenarians according to an epigenetic biomarker of tissue age known as [[epigenetic clock]]: it is about 15 years younger than expected in a centenarian.<ref>{{cite journal | vauthors = Horvath S, Mah V, Lu AT, Woo JS, Choi OW, Jasinska AJ, Riancho JA, Tung S, Coles NS, Braun J, Vinters HV, Coles LS | title = The cerebellum ages slowly according to the epigenetic clock | journal = Aging | volume = 7 | issue = 5 | pages = 294–306 | date = May 2015 | pmid = 26000617 | pmc = 4468311 | doi = 10.18632/aging.100742 | url = https://www.aging-us.com/article/100742/text }}</ref> Further, [[gene expression]] patterns in the human cerebellum show less [[aging brain|age-related]] alteration than that in the [[cerebral cortex]].<ref>{{cite journal | vauthors = Fraser HB, Khaitovich P, Plotkin JB, Pääbo S, Eisen MB | title = Aging and gene expression in the primate brain | journal = PLOS Biology | volume = 3 | issue = 9 | pages = e274 | date = September 2005 | pmid = 16048372 | pmc = 1181540 | doi = 10.1371/journal.pbio.0030274 | author-link4 = Svante Pääbo | doi-access = free }}</ref>
Some studies have reported reductions in numbers of cells or volume of tissue, but the amount of data relating to this question is not very large.<ref>{{cite journal | vauthors = Andersen BB, Gundersen HJ, Pakkenberg B | title = Aging of the human cerebellum: a stereological study | journal = Journal of Comparative Neurology | volume = 466 | issue = 3 | pages = 356–65 | date = November 2003 | pmid = 14556293 | doi = 10.1002/cne.10884 | s2cid = 7091227 }}</ref><ref>{{cite journal | vauthors = Raz N, Gunning-Dixon F, Head D, Williamson A, Acker JD | title = Age and sex differences in the cerebellum and the ventral pons: a prospective MR study of healthy adults | journal = American Journal of Neuroradiology | volume = 22 | issue = 6 | pages = 1161–7 | year = 2001 | pmid = 11415913 | pmc = 7974784 | url = http://www.ajnr.org/cgi/reprint/22/6/1161.pdf | archive-url = https://web.archive.org/web/20081217005530/http://www.ajnr.org/cgi/reprint/22/6/1161.pdf | url-status = live | archive-date = 2008-12-17 }}</ref>