Editing Thyroid (section)

====Graves' disease====
{{main|Graves' disease}}
[[Graves' disease]] is an autoimmune disorder that is the most common cause of hyperthyroidism.<ref name=":0">{{cite journal | vauthors = Smith TJ, Hegedüs L | title = Graves' Disease | language = EN | journal = The New England Journal of Medicine | volume = 375 | issue = 16 | pages = 1552–1565 | date = October 2016 | pmid = 27797318 | doi = 10.1056/nejmra1510030 | url = https://findresearcher.sdu.dk:8443/ws/files/128446579/Graves_Disease.pdf | access-date = 2020-07-22 | archive-date = 2020-08-01 | archive-url = https://web.archive.org/web/20200801093036/https://findresearcher.sdu.dk:8443/ws/files/128446579/Graves_Disease.pdf | url-status = dead }}</ref> In Graves' disease, for an unknown reason [[autoantibody|autoantibodies]] develop against the thyroid stimulating hormone receptor. These antibodies activate the receptor, leading to development of a goitre and symptoms of hyperthyroidism, such as heat intolerance, weight loss, diarrhoea and palpitations. Occasionally such antibodies block but do not activate the receptor, leading to symptoms associated with hypothyroidism.<ref name=":0" /> In addition, gradual protrusion of the eyes may occur, called [[Graves' ophthalmopathy]], as may swelling of the front of the shins.<ref name=":0" /> Graves' disease can be diagnosed by the presence of [[Pathognomonic|pathomnomonic]] features such as involvement of the eyes and shins, or isolation of autoantibodies, or by results of a radiolabelled uptake scan. Graves' disease is treated with anti-thyroid drugs such as propylthiouracil, which decrease the production of thyroid hormones, but hold a high rate of relapse. If there is no involvement of the eyes, then use of radioactive isotopes to ablate the gland may be considered. Surgical removal of the gland with subsequent thyroid hormone replacement may be considered, however this will not control symptoms associated with the eye or skin.<ref name=":0" />