Editing Statin (section)

===Increasing LDL uptake===
In rabbits, [[hepatocyte|liver cells]] sense the reduced levels of liver cholesterol and seek to compensate by synthesizing [[LDL receptor]]s to draw cholesterol out of the circulation.<ref name="Ma1986">{{cite journal | vauthors = Ma PT, Gil G, Südhof TC, Bilheimer DW, Goldstein JL, Brown MS | title = Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 21 | pages = 8370–8374 | date = November 1986 | pmid = 3464957 | pmc = 386930 | doi = 10.1073/pnas.83.21.8370 | doi-access = free | title-link = doi | bibcode = 1986PNAS...83.8370M }}</ref> This is accomplished via [[protease]]s that cleave membrane-bound [[sterol regulatory element binding protein]]s, which then migrate to the [[cell nucleus|nucleus]] and bind to the sterol response elements. The sterol response elements then facilitate increased transcription of various other proteins, most notably, [[LDL receptor]]. The LDL receptor is transported to the liver [[cell membrane]] and binds to passing [[low density lipoprotein|LDL]] and [[very low density lipoprotein|VLDL]] particles, mediating their uptake into the liver, where the cholesterol is reprocessed into bile salts and other byproducts. This results in a net effect of less LDL circulating in blood.{{cn|date=May 2024}}