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===Health=== O'Donnell has suffered with mental issues her entire life, attributing it to the sexual abuse that was inflicted on her by her father when she was a child. She struggles with major depressive disorder, PTSD, anxiety issues, and body-image issues and takes antidepressants. On her body-image struggles, she said, “I think it’s what your body does to protect you if you’re a kid who’s sexually abused, which I was.”<ref>{{cite web |title=Rosie O'Donnell Says She Was Sexually Abused by Her Father as a Child |url=https://www.etonline.com/rosie-odonnell-says-she-was-sexually-abused-by-her-father-as-a-child-121428 |website=Entertainment Tonight |date=March 13, 2019}}</ref><ref>{{cite web |title=Rosie O'Donnell is bingeing on Pop Tarts and stressing about leaving the house |url=https://pagesix.com/2020/05/12/rosie-odonnell-is-being-extra-vigilant-because-of-heart-history/ |website=Page Six |date=May 12, 2020}}</ref><ref>{{cite web |title=How Rosie O'Donnell Beat Depression |url=https://abcnews.go.com/GMA/Depression/story?id=126783 |website=ABC News |date=August 8, 2001}}</ref> In the summer of 2000, O'Donnell suffered a [[staph]] infection after she accidentally cut the middle finger of her left hand with a knife while cutting a price tag off a fishing pole.<ref name="burned up"/> The infection incapacitated her for weeks and nearly resulted in doctors amputating her hand.<ref>{{Cite web |last= |first= |title=Rosie O'Donnell Released From Hospital |url=https://abcnews.go.com/Entertainment/story?id=107001&page=1 |access-date=June 22, 2023 |website=ABC News |language=en}}</ref> She later quipped that George W. Bush was to blame for the infection, saying that she was preparing to go on a fishing trip at the time to avoid seeing Bush on television during the then-ongoing [[2000 Republican National Convention]].<ref name="burned up"/> O'Donnell has acknowledged her struggles with recurrent [[major depressive episode]]s during the fall and winter months consistent with [[seasonal affective disorder]].<ref>{{cite news|url=https://www.washingtonpost.com/wp-dyn/content/article/2007/03/07/AR2007030700984.html|title=Rosie Says She's Treated for Depression|newspaper=[[The Washington Post]]|access-date=July 2, 2017}}</ref> In 2008, O'Donnell denied she is an alcoholic and claimed to have temporarily given up alcohol to lose weight. She wrote on her blog: “‘Cause I was drinking too much, ’cause I didn’t want to any more, ’cause it is hard to lose weight when drinking, ’cause I can never have only one.”<ref>{{cite web |title=Rosie O'Donnell Gives Up Alcohol |url=https://people.com/celebrity/rosie-odonnell-gives-up-alcohol/ |website=People |date=February 7, 2008}}</ref> O'Donnell suffered a heart attack in mid-August 2012. She said an artery was 99 percent blocked and a [[stent]] was inserted.<ref>{{cite news|title=Rosie O'Donnell: Comedian suffers heart attack, gets stent |url=http://www.washingtontimes.com/news/2012/aug/20/rosie-odonnell-has-heart-attack-gets-stent/|newspaper=The Washington Post |agency=Associated Press |date= August 20, 2012|access-date=December 20, 2016 }}{{cbignore|bot=medic}}</ref><ref>{{cite web|url=http://rosie.com/my-heart-attack/|first=Rosie|last=O'Donnell|publisher=Rosie.com (official site)|title=My Heart Attack|date=August 20, 2012|access-date=August 20, 2012}}</ref> She later revealed on Twitter that to reverse her heart disease, she would espouse the whole foods, [[plant-based diet]] promoted by [[Caldwell Esselstyn]].<ref>{{cite web|url=http://www.ecorazzi.com/2012/08/23/rosie-odonnell-embraces-plant-based-diet-after-heart-attack/|title=Rosie O'Donnell Embraces Plant-Based Diet after Heart Attack|last=Koerner|first=Allyson|quote=nine days later – nine pounds lost – eating a plant based diet #likebillclinton pic.twitter.com/8ItILfpl. {{sic}}|date=August 23, 2012|access-date=August 26, 2012|archive-date=August 26, 2018|archive-url=https://web.archive.org/web/20180826165859/http://www.ecorazzi.com/2012/08/23/rosie-odonnell-embraces-plant-based-diet-after-heart-attack/|url-status=usurped}}</ref> O'Donnell has type 2 diabetes.<ref>{{cite web |title=Rosie O'Donnell, 62, Details 'Shocking' Weight Loss |url=https://www.mensjournal.com/entertainment/rosie-odonnell-details-shocking-weight-loss |website=Men's Journal |date=March 21, 2025}}</ref>
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