Editing Reelin (section)

===Temporal lobe epilepsy: granule cell dispersion===
Decreased reelin expression in the hippocampal tissue samples from patients with [[temporal lobe epilepsy]] was found to be directly correlated with the extent of [[granule cell]] dispersion (GCD), a major feature of the disease that is noted in 45%–73% of patients.<ref name="TLE1" /><ref name="TLE2" /> The dispersion, according to a small study, is associated with the RELN promoter hypermethylation.<ref name="pmid19287316" /> According to one study, prolonged seizures in a rat model of mesial temporal lobe epilepsy have led to the loss of reelin-expressing interneurons and subsequent ectopic chain migration and aberrant integration of newborn dentate granule cells. Without reelin, the chain-migrating neuroblasts failed to detach properly.<ref name="Gonq_2007" /> Moreover, in a [[kainate]]-induced mouse epilepsy model, exogenous reelin had prevented GCD, according to one study.<ref name="pmid19185570" />