Editing Palladium (section)

===Precautions===
Like other [[platinum-group metal]]s, bulk Pd is quite inert. Although [[contact dermatitis]] has been reported, data on the effects are limited. It has been shown that people with an allergic reaction to palladium also react to nickel, making it advisable to avoid the use of dental alloys containing palladium on those so allergic.<ref name="Kiel">{{cite journal |last1=Kielhorn |first1=Janet |last2=Melber |first2=Christine |last3=Keller |first3=Detlef |last4=Mangelsdorf |first4=Inge |title=Palladium – A review of exposure and effects to human health |journal=International Journal of Hygiene and Environmental Health |volume=205 |issue=6 |pages=417–32 |date=2002 |pmid=12455264 |doi=10.1078/1438-4639-00180 |bibcode=2002IJHEH.205..417K}}</ref><ref>{{cite book |pages=549–563 |chapter=Health Risk Potential of Palladium |chapter-url=https://books.google.com/books?id=OnNZqylS_Z8C&pg=PA549 |title=Palladium emissions in the environment: analytical methods, environmental assessment and health effects |first1=Fathi |last1=Zereini |first2=Friedrich |last2=Alt |publisher=Springer Science & Business |date=2006 |isbn=978-3-540-29219-7}}</ref><ref>{{cite journal |last1=Wataha |first1=J. C. |last2=Hanks |first2=C. T. |title=Biological effects of palladium and risk of using palladium in dental casting alloys |journal=Journal of Oral Rehabilitation |volume=23 |issue=5 |pages=309–20 |date=1996 |pmid=8736443 |doi=10.1111/j.1365-2842.1996.tb00858.x}}</ref><ref>{{cite journal |last1=Aberer |first1=Werner |last2=Holub |first2=Henriette |last3=Strohal |first3=Robert |last4=Slavicek |first4=Rudolf |title=Palladium in dental alloys – the dermatologists' responsibility to warn? |journal=Contact Dermatitis |volume=28 |issue=3 |pages=163–5 |date=1993 |pmid=8462294 |doi=10.1111/j.1600-0536.1993.tb03379.x |s2cid=43020912}}</ref><ref>{{cite journal |last1=Wataha |first1=John C. |last2=Shor |first2=Kavita |title=Palladium alloys for biomedical devices |journal=Expert Review of Medical Devices |volume=7 |issue=4 |pages=489–501 |date=2010 |pmid=20583886 |doi=10.1586/erd.10.25 |s2cid=41325428}}</ref>

Some palladium is emitted with the exhaust gases of cars with [[catalytic converter]]s. Between 4 and 108&nbsp;ng/km of palladium particulate is released by such cars, while the total uptake from food is estimated to be less than 2&nbsp;μg per person a day. The second possible source of palladium is dental restoration, from which the uptake of palladium is estimated to be less than 15&nbsp;μg per person per day. People working with palladium or its compounds might have a considerably greater uptake. For soluble compounds such as [[palladium chloride]], 99% is eliminated from the body within three days.<ref name="Kiel" />

The [[median lethal dose]] (LD<sub>50</sub>) of soluble palladium compounds in mice is 200&nbsp;mg/kg for [[oral administration|oral]] and 5&nbsp;mg/kg for [[intravenous administration]].<ref name="Kiel" />