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Ehlers–Danlos syndrome
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===Skin=== The weak connective tissue causes abnormal skin. This may present as stretchy or in other types simply be velvet soft. In all types, some increased fragility occurs, but the degree varies depending on the underlying subtype. The skin may tear and bruise easily, and may heal with abnormal atrophic scars;<ref name="mayoclinic"/> atrophic scars that look like cigarette paper are a sign seen including in those whose skin might appear otherwise normal.<ref name="NIHGHR2016"/><ref name="Byers2012"/><ref name = "Malfait_2018" /> In some subtypes, though not the hypermobile subtype, redundant skin folds occur, especially on the eyelids. Redundant skin folds are areas of excess skin lying in folds.<ref name="mayoclinic"/><ref>{{cite web|url=http://morphopedics.wikidot.com/ehlers-danlos-syndrome|title=Ehlers Danlos Syndrome – Morphopedics|website=morphopedics.wikidot.com|access-date=2018-06-15}}</ref> Other skin symptoms include molluscoid pseudotumors,<ref name="ehlersdanlosnetwork">{{cite web|url=http://www.ehlersdanlosnetwork.org/classical.html|title=Classical Type-EDS|work=Ehlers–Danlos Syndrome Network C.A.R.E.S Inc.|archive-url=https://web.archive.org/web/20120530034615/http://www.ehlersdanlosnetwork.org/classical.html|archive-date=2012-05-30|url-status=dead|access-date=2012-05-25}}</ref> especially on pressure points, [[petechia]]e,<ref>{{cite book|url=https://books.google.com/books?id=gU4Lfsess6cC&pg=PA465|title=Portable Signs and Symptoms |date=2007|publisher=Lippincott Williams & Wilkins|isbn=9781582556796|page=465|archive-url=https://web.archive.org/web/20171105195522/https://books.google.com/books?id=gU4Lfsess6cC&pg=PA465|archive-date=2017-11-05|url-status=live}}</ref> subcutaneous spheroids,<ref name="ehlersdanlosnetwork"/> [[livedo reticularis]]; [[piezogenic papules]] are less common.<ref>{{cite web|url=https://www.dermnetnz.org/topics/piezogenic-papules|title=Piezogenic papules – DermNet New Zealand|website=www.dermnetnz.org|archive-url=https://web.archive.org/web/20161126001705/https://www.dermnetnz.org/topics/piezogenic-papules|archive-date=2016-11-26|url-status=live}}</ref> In vascular EDS, skin can also be thin and translucent. In dermatosparaxis EDS, the skin is extremely fragile and saggy.<ref name="NIHGHR2016" /> <gallery mode="packed"> File:Atrophic scar of Ehlers Danlos syndrome.jpg|Atrophic scar in a case of EDS File:PMC3567970 1752-1947-7-35-1 (cropped).png|Translucent skin in vascular EDS File:Ehlers-Danlos syndrome4.jpg|Individual with EDS displaying skin hyperelasticity File:Piezogenic papules.jpg|Piezogenic papules on the heel of an individual with hypermobile EDS File:Skinhyperelasticity-1.jpg|Skin hyperelasticity in the wrist </gallery>
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