Editing Coenzyme Q10 (section)

==Adverse effects and precautions==
Generally, oral CoQ<sub>10</sub> supplementation is well tolerated.<ref name=lpi/> The most common side effects are gastrointestinal symptoms ([[nausea]], vomiting, [[appetite suppression]], and [[abdominal pain]]), [[rash]]es, and headaches.<ref name="pmid20601617">{{cite journal | vauthors = Wyman M, Leonard M, Morledge T | title = Coenzyme Q10: a therapy for hypertension and statin-induced myalgia? | journal = Cleveland Clinic Journal of Medicine | volume = 77 | issue = 7 | pages = 435–442 | date = July 2010 | pmid = 20601617 | doi = 10.3949/ccjm.77a.09078 | s2cid = 26572524 | doi-access = free }}</ref> Some adverse effects, largely gastrointestinal, are reported with intakes.<ref name=sood/> Doses of 100–300&nbsp;mg per day may induce [[insomnia]] or elevate [[Liver function tests|liver enzymes]].<ref name=sood/> The observed safe level risk assessment method indicated that the evidence of safety is acceptable at intakes up to 1200&nbsp;mg per day.<ref name="pmid16814438">{{cite journal | vauthors = Hathcock JN, Shao A | title = Risk assessment for coenzyme Q10 (Ubiquinone) | journal = Regulatory Toxicology and Pharmacology | volume = 45 | issue = 3 | pages = 282–288 | date = August 2006 | pmid = 16814438 | doi = 10.1016/j.yrtph.2006.05.006 }}</ref>

Caution should be observed in the use of CoQ<sub>10</sub> supplementation in people with bile duct obstruction and during pregnancy or breastfeeding.<ref name=sood/>