Editing Aspirin (section)

===Fever===
Like its ability to control pain, aspirin's ability to control [[fever]] is due to its action on the [[prostaglandin]] system through its irreversible inhibition of [[COX]].<ref>{{cite journal | vauthors = Bartfai T, Conti B | title = Fever | journal = TheScientificWorldJournal | volume = 10 | pages = 490–503 | date = March 2010 | pmid = 20305990 | pmc = 2850202 | doi = 10.1100/tsw.2010.50 | doi-access = free }}</ref> Although aspirin's use as an [[antipyretic]] in adults is well established, many medical societies and regulatory agencies, including the [[American Academy of Family Physicians]], the [[American Academy of Pediatrics]], and the [[Food and Drug Administration]], strongly advise against using aspirin for the treatment of fever in children because of the risk of [[Reye syndrome]], a rare but often fatal illness associated with the use of aspirin or other salicylates in children during episodes of viral or bacterial infection.<ref>{{cite journal | vauthors = Pugliese A, Beltramo T, Torre D | title = Reye's and Reye's-like syndromes | journal = Cell Biochemistry and Function | volume = 26 | issue = 7 | pages = 741–6 | date = October 2008 | pmid = 18711704 | doi = 10.1002/cbf.1465 | s2cid = 22361194 }}</ref><ref>{{cite journal | vauthors = Beutler AI, Chesnut GT, Mattingly JC, Jamieson B | title = FPIN's Clinical Inquiries. Aspirin use in children for fever or viral syndromes | journal = American Family Physician | volume = 80 | issue = 12 | pages = 1472 | date = December 2009 | pmid = 20000310 }}</ref><ref name=AAPweb>{{cite web|title=Medications Used to Treat Fever|date=29 June 2012 |url=http://www.healthychildren.org/English/health-issues/conditions/fever/Pages/Medications-Used-to-Treat-Fever.aspx|publisher=American Academy of Pediatrics|access-date=25 November 2012|url-status=live|archive-url=https://web.archive.org/web/20130218084054/http://www.healthychildren.org/English/health-issues/conditions/fever/Pages/Medications-Used-to-Treat-Fever.aspx|archive-date=18 February 2013}}</ref> Because of the risk of Reye syndrome in children, in 1986, the US [[Food and Drug Administration]] (FDA) required labeling on all aspirin-containing medications advising against its use in children and teenagers.<ref name="FDA 1986 FR">{{cite journal|title=51 FR 8180|url=https://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Over-the-CounterOTCDrugs/StatusofOTCRulemakings/UCM078593.pdf|journal=United States Federal Register|volume=51|issue=45|date=7 March 1986|url-status=dead|archive-url=https://web.archive.org/web/20110819130409/https://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Over-the-CounterOTCDrugs/StatusofOTCRulemakings/UCM078593.pdf|archive-date=19 August 2011}}</ref>