Editing Adenosine (section)

=== Sleep ===
Adenosine is a key factor in regulating the body's [[Circadian rhythm|sleep-wake cycle]].<ref>{{cite journal | vauthors = Reichert CF, Deboer T, Landolt HP | title = Adenosine, caffeine, and sleep-wake regulation: state of the science and perspectives | journal = Journal of Sleep Research | volume = 31 | issue = 4 | pages = e13597 | date = August 2022 | pmid = 35575450 | pmc = 9541543 | doi = 10.1111/jsr.13597 }}</ref> Adenosine levels bulid up in the brain during periods of wakefulness, causing a need to sleep when level become too high and lowers during periods of sleep, giving a sensation of restedness when waking. Higher adenosine levels correlate with a stronger feeling of [[sleepiness]], also known as sleep drive or sleep pressure.<ref>{{Cite web |date=2022-06-07 |title=Adenosine and Sleep |url=https://www.sleepfoundation.org/how-sleep-works/adenosine-and-sleep |access-date=2023-04-12 |website=Sleep Foundation |language=en-US}}</ref> [[Cognitive behavioral therapy for insomnia]] (CBT-I), which is considered one of the most effective treatments for [[insomnia]], utilizes short-term [[sleep deprivation]] to raise and regulate adenosine levels in the body, for the intended promotion of consistent and sustained sleep in the long term.<ref>{{cite journal | vauthors = Perlis M, Shaw PJ, Cano G, Espie CA | title = Models of insomnia. | journal = Principles and Practice of Sleep Medicine. | date = January 2011 | volume = 5 | issue = 1 | pages = 850–865 | publisher = Elsevier Inc. | doi = 10.1016/B978-1-4160-6645-3.00078-5 | isbn = 9781416066453 | url = https://www.med.upenn.edu/cbti/assets/user-content/documents/ppsmmodelsofinsomnia20115theditionproof.pdf }}</ref> 

A principal component of [[Cannabis (drug)|cannabis]] [[Tetrahydrocannabinol|delta-9-tetrahydrocannabinol]] (THC) and the [[Endocannabinoid system|endocannabinoid]] [[anandamide]] (AEA) induces [[sleep]] in [[rat]]s by increasing adenosine levels in the [[basal forebrain]]. These components also significantly increase [[slow-wave sleep]] during the [[sleep cycle]], mediated by [[CB1 receptor]] [[Cannabinoid agonist|activation]]. These findings identify a potential [[Medical cannabis|therapeutic use]] of [[cannabinoid]]s to induce sleep in conditions where sleep may be severely attenuated.<ref>{{Cite journal | vauthors = Murillo-Rodriguez E, Blanco-Centurion C, Sanchez C, Piomelli D, Shiromani PJ | title = Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study | journal = Sleep | volume = 26 | issue = 8 | pages = 943–947 | date = December 2003 | pmid = 14746372 | doi = 10.1093/sleep/26.8.943 | doi-access = free }}</ref>