Editing Zebrafish (section)

====Background genetics====
[[Inbred strains]] and traditional outbred stocks have not been developed for laboratory zebrafish, and the genetic variability of wild-type lines among institutions may contribute to the [[replication crisis]] in biomedical research.<ref>{{cite journal |vauthors=Crim MJ, Lawrence C |title=A fish is not a mouse: understanding differences in background genetics is critical for reproducibility |journal=Lab Animal |volume=50 |issue=1 |pages=19–25 |date=January 2021 |pmid=33268901 |doi=10.1038/s41684-020-00683-x |issn=0093-7355 |s2cid=227259359}}</ref> Genetic differences in wild-type lines among populations maintained at different research institutions have been demonstrated using both [[Single-nucleotide polymorphism]]s<ref>{{cite journal |vauthors=Whiteley AR, Bhat A, Martins EP, Mayden RL, Arunachalam M, Uusi-Heikkilä S, Ahmed AT, Shrestha J, Clark M, Stemple D, Bernatchez L |display-authors=6 |title=Population genomics of wild and laboratory zebrafish (''Danio rerio'') |journal=Molecular Ecology |volume=20 |issue=20 |pages=4259–4276 |date=October 2011 |pmid=21923777 |pmc=3627301 |doi=10.1111/j.1365-294X.2011.05272.x |bibcode=2011MolEc..20.4259W}}</ref> and [[microsatellite]] analysis.<ref>{{cite journal |vauthors=Coe TS, Hamilton PB, Griffiths AM, Hodgson DJ, Wahab MA, Tyler CR |title=Genetic variation in strains of zebrafish (''Danio rerio'') and the implications for ecotoxicology studies |journal=Ecotoxicology |volume=18 |issue=1 |pages=144–150 |date=January 2009 |pmid=18795247 |doi=10.1007/s10646-008-0267-0 |bibcode=2009Ecotx..18..144C |s2cid=18370151}}</ref>