Editing Salmonella (section)

== Resistance to oxidative burst ==
A hallmark of ''Salmonella'' pathogenesis is the ability of the bacterium to survive and proliferate within [[phagocyte]]s.  Phagocytes produce DNA-damaging agents such as [[nitric oxide]] and oxygen [[Radical (chemistry)|radicals]] as a defense against pathogens. Thus, ''Salmonella'' species must face attack by molecules that challenge genome integrity. Buchmeier'' et al.''<ref name=Buchmeier>{{cite journal | vauthors = Buchmeier NA, Lipps CJ, So MY, Heffron F | title = Recombination-deficient mutants of Salmonella typhimurium are avirulent and sensitive to the oxidative burst of macrophages | journal = Molecular Microbiology | volume = 7 | issue = 6 | pages = 933–936 | date = March 1993 | pmid = 8387147 | doi = 10.1111/j.1365-2958.1993.tb01184.x | s2cid = 25127127 }}</ref> showed that mutants of ''S. enterica'' lacking RecA or RecBC protein function are highly sensitive to oxidative compounds synthesized by macrophages, and furthermore these findings indicate that successful systemic infection by ''S. enterica'' requires RecA- and RecBC-mediated recombinational repair of DNA damage.<ref name=Buchmeier /><ref name="pmid11751841">{{cite journal | vauthors = Cano DA, Pucciarelli MG, García-del Portillo F, Casadesús J | title = Role of the RecBCD recombination pathway in Salmonella virulence | journal = Journal of Bacteriology | volume = 184 | issue = 2 | pages = 592–595 | date = January 2002 | pmid = 11751841 | pmc = 139588 | doi = 10.1128/jb.184.2.592-595.2002 }}</ref>