Editing Protein tertiary structure (section)

=== Protein aggregation diseases ===
[[Protein aggregation]] diseases such as [[Alzheimer's disease]] and [[Huntington's disease]] and [[prion]] diseases such as [[bovine spongiform encephalopathy]] can be better understood by constructing (and reconstructing) [[disease model]]s. This is done by causing the disease in laboratory animals, for example, by administering a [[toxin]], such as [[MPTP]] to cause Parkinson's disease, or through [[genetic engineering|genetic manipulation]].<ref name="park">{{cite journal|title=Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP|pmid=15503155|doi=10.1007/s00441-004-0938-y | volume=318|issue=1|date=October 2004|journal=Cell Tissue Res.|pages=215–24|author=Schober A|s2cid=1824912}}</ref><ref name="ko">{{cite web|url=http://www.sigmaaldrich.com/catalog/genes/TP53|title=Tp53 Knockout Rat|publisher=Cancer|access-date=2010-12-18}}</ref>
[[Protein structure prediction]] is a new way to create disease models, which may avoid the use of animals.<ref name="bit">{{cite web|url=http://www.bit-tech.net/hardware/graphics/2009/06/15/what-is-folding-and-why-does-it-matter/|title=Feature – What is Folding and Why Does it Matter?|access-date=December 18, 2010|archive-url=https://web.archive.org/web/20131212083942/http://www.bit-tech.net/hardware/graphics/2009/06/15/what-is-folding-and-why-does-it-matter/|archive-date=December 12, 2013|url-status=dead}}</ref>