Editing Palladium (section)

===Toxicity===
{{Chembox
| container_only = yes
|Section7={{Chembox Hazards
| ExternalSDS =
| GHSPictograms = {{GHS07}}
| GHSSignalWord = Warning
| HPhrases = {{H-phrases|H317|}}
| PPhrases = {{P-phrases|P261|P273|P280|P302+352|P321|P333+313|P363|P501}}<ref>{{Sigma-Aldrich|id=373192|name=SDS Palladium|date=12-10-2022}}</ref>
| NFPA-H = 0
| NFPA-F = 0
| NFPA-R = 0
| NFPA-S =
| NFPA_ref =
 }}
}}
Palladium is a metal with low toxicity as conventionally measured (e.g. [[Median lethal dose|LD<sub>50</sub>]]). Recent research on the mechanism of palladium toxicity suggests high toxicity if measured on a longer timeframe and at the cellular level in the liver and kidney.<ref>Hosseini et al, Metallomics, 2016,8, 252–259; {{doi|10.1039/C5MT00249D}}</ref> Mitochondria appear to have a key role in palladium toxicity via mitochondrial membrane potential collapse and depletion of the cellular glutathione (GSH) level. Until that recent work, it had been thought that palladium was poorly absorbed by the [[human body]] when [[ingested]]. Plants such as the [[water hyacinth]] are killed by low levels of palladium salts, but most other plants tolerate it, although tests show that, at levels above 0.0003%, growth is affected. High doses of palladium could be poisonous; tests on [[rodents]] suggest it may be [[carcinogenic]], though until the recent research cited above, no clear evidence indicated that the element harms humans.<ref>{{cite book |first=John |last=Emsley |title=Nature's Building Blocks: An A-Z Guide to the Elements |publisher=Oxford University Press |isbn=978-0-19-960563-7 |pages=384, 387 |date=2011}}</ref>