Editing Marfan syndrome (section)

===Pregnancy===
During pregnancy, even in the absence of preconception cardiovascular abnormality, women with Marfan syndrome are at significant risk of aortic dissection, which is often fatal even when rapidly treated. Women with Marfan syndrome, then, should receive a thorough assessment prior to conception, and [[echocardiography]] should be performed every six to 10 weeks during pregnancy, to assess the aortic root diameter. For most women, safe vaginal delivery is possible.<ref name="emed">{{cite journal | vauthors = Haskett D, Doyle JJ, Gard C, Chen H, Ball C, Estabrook MA, Encinas AC, Dietz HC, Utzinger U, Vande Geest JP, Azhar M | display-authors = 6 | title = Altered tissue behavior of a non-aneurysmal descending thoracic aorta in the mouse model of Marfan syndrome | journal = Cell and Tissue Research | volume = 347 | issue = 1 | pages = 267–277 | date = January 2012 | pmid = 22105919 | doi = 10.1007/s00441-011-1270-y | url = http://emedicine.medscape.com/article/946315-print | access-date = June 25, 2007 | url-status = live | s2cid = 14333291 | archive-url = https://web.archive.org/web/20090706022447/http://emedicine.medscape.com/article/946315-print | archive-date = July 6, 2009 }}</ref>

[[Prenatal testing]] can be performed in females with Marfan syndrome to determine if the condition has been inherited in their child.<ref name=":2" /> At 10 to 12 weeks of pregnancy, examining a piece of placental tissue through a test called chorionic villus sampling can be performed to make a diagnosis.<ref name=":2" /> Another prenatal test can be performed called [[amniocentesis]] at 16 to 18 weeks of pregnancy.<ref name=":2" />

Marfan syndrome is expressed dominantly. This means a child with one parent a bearer of the gene has a 50% probability of getting the syndrome. In 1996, the first [[Preimplantation genetic diagnosis|preimplantation genetic testing]] (PGT) therapy for Marfan was conducted;<ref name="PGT">{{cite journal | vauthors = Harton GL, Tsipouras P, Sisson ME, Starr KM, Mahoney BS, Fugger EF, Schulman JD, Kilpatrick MW, Levinson G, Black SH | display-authors = 6 | title = Preimplantation genetic testing for Marfan syndrome | journal = Molecular Human Reproduction | volume = 2 | issue = 9 | pages = 713–715 | date = September 1996 | pmid = 9239687 | doi = 10.1093/molehr/2.9.713 | doi-access = free }}</ref> in essence PGT means conducting a genetic test on early-stage [[in vitro fertilization|IVF]] embryo cells and discarding those embryos affected by the Marfan mutation.