Editing Jet lag (section)

===Pharmaceutical Treatment===
The short-term use of [[hypnotic]] medication has shown efficacy in reducing insomnia related to jet lag.<ref>{{cite journal |last1=Suhner |first1=A. |last2=Schlagenhauf |first2=P. |last3=Höfer |first3=I. |last4=Johnson |first4=R. |last5=Tschopp |first5=A. |last6=Steffen |first6=R. |title=Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag |journal=Aviation, Space, and Environmental Medicine |date=July 2001 |volume=72 |issue=7 |pages=638–646 |pmid=11471907 }}</ref><ref>{{cite journal |last1=Reilly |first1=T. |title=Effect of Low-Dose Temazepam on Physiological Variables and Performance Tests Following a Westerly Flight Across Five Time Zones |journal=International Journal of Sports Medicine |date=31 December 2001 |volume=22 |issue=3 |pages=166–174 |doi=10.1055/s-2001-16379 |pmid=11354518 }}</ref> In a study, [[zolpidem]] improved sleep quality and reduced awakenings for people travelling across five to nine time zones.<ref>{{cite journal |last1=Jamieson |first1=Andrew O. |last2=Zammit |first2=Gary K. |last3=Rosenberg |first3=Richard S. |last4=Davis |first4=Jeffrey R. |last5=Walsh |first5=James K. |title=Zolpidem reduces the sleep disturbance of jet lag |journal=Sleep Medicine |date=September 2001 |volume=2 |issue=5 |pages=423–430 |doi=10.1016/s1389-9457(00)00073-3 |pmid=14592392 }}</ref> The potential adverse effects of hypnotic agents, like amnesia and confusion, have led some doctors to advise patients to test such medications prior to using them for treating jet lag.<ref>{{cite journal |last1=Dolder |first1=Christian R |last2=Nelson |first2=Michael H |title=Hypnosedative-Induced Complex Behaviours: Incidence, Mechanisms and Management |journal=CNS Drugs |date=2008 |volume=22 |issue=12 |pages=1021–1036 |doi=10.2165/0023210-200822120-00005 |pmid=18998740 }}</ref><ref>{{Cite web |date=2016-12-07 |title=Should You Take Sleeping Pills on a Flight? |url=https://www.cntraveler.com/story/should-you-take-sleeping-pills-on-a-flight |access-date=2023-07-27 |website=Condé Nast Traveler |language=en-US}}</ref> Several cases using [[triazolam]] to promote sleep during a flight reported dramatic [[global amnesia]].<ref>{{cite journal |last1=Morris |first1=H. H. |title=Traveler's amnesia. Transient global amnesia secondary to triazolam |journal=JAMA |date=21 August 1987 |volume=258 |issue=7 |pages=945–946 |doi=10.1001/jama.258.7.945 |pmid=3613025 }}</ref>

[[Cordycepin]], a derivative of a natural fungal compound, has been shown to be a potential [[modulator]] of the circadian clock.<ref>{{Cite web |last1=Yirka |first1=Bob |last2=Xpress |first2=Medical |title=Protein found that keeps the circadian clock on schedule |url=https://medicalxpress.com/news/2020-05-protein-circadian-clock.html |access-date=2025-04-24 |website=medicalxpress.com |language=en}}</ref> Administration of synthetic cordycepin in mice accelerated circadian [[Entrainment (chronobiology)|re-entrainment]] following an abrupt shift in the light-dark cycle. The compound was found to interact with the [[RUVBL2|RUVBL2 protein]], which influences gene transcription associated with circadian timing. These findings suggest a possible future application of circadian-targeting compounds as [[Pharmacotherapy|pharmacological therapeutics]] for jet lag and other circadian sleep-wake disorders.