Editing Cilium (section)

===Axo-ciliary synapse===
With axo-ciliary [[synapse]]s,<!-- first reported in 2022,--> there is communication between [[Serotonin|serotonergic]] [[axon]]s and <!--at least the -->primary cilia of [[Hippocampus anatomy#Basic hippocampal circuit|CA1]] [[Pyramidal cell|pyramidal]] [[neuron]]s that alters the neuron's [[epigenetic]] state in the [[Cell nucleus|nucleus]] – "a way to change what is being transcribed or made in the nucleus" via this signalling distinct from that at the [[plasma membrane]] which also is longer-term.<ref>{{cite news |last1=Tamim |first1=Baba |title=New discovery: Synapse hiding in the mice brain may advance our understanding of neuronal communication |url=https://interestingengineering.com/science/new-discovery-synapse-hiding-in-mice-brain |access-date=19 October 2022 |work=interestingengineering.com |date=4 September 2022}}</ref><ref>{{cite journal |last1=Sheu |first1=Shu-Hsien |last2=Upadhyayula |first2=Srigokul |last3=Dupuy |first3=Vincent |last4=Pang |first4=Song |last5=Deng |first5=Fei |last6=Wan |first6=Jinxia |last7=Walpita |first7=Deepika |last8=Pasolli |first8=H. Amalia |last9=Houser |first9=Justin |last10=Sanchez-Martinez |first10=Silvia |last11=Brauchi |first11=Sebastian E. |last12=Banala |first12=Sambashiva |last13=Freeman |first13=Melanie |last14=Xu |first14=C. Shan |last15=Kirchhausen |first15=Tom |last16=Hess |first16=Harald F. |last17=Lavis |first17=Luke |last18=Li |first18=Yulong |last19=Chaumont-Dubel |first19=Séverine |last20=Clapham |first20=David E. |title=A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility |journal=Cell |date=1 September 2022 |volume=185 |issue=18 |pages=3390–3407.e18 |doi=10.1016/j.cell.2022.07.026 |pmid=36055200 |pmc=9789380 |s2cid=251958800 |language=English |issn=0092-8674}}
* University press release: {{cite news |title=Scientists discover new kind of synapse in neurons' tiny hairs |url=https://phys.org/news/2022-09-scientists-kind-synapse-neurons-tiny.html |access-date=19 October 2022 |work=Howard Hughes Medical Institute via phys.org |language=en}}</ref>