Editing Cholera (section)

=== Antibiotics ===
[[Antibiotic]] treatments for one to three days shorten the course of the disease and reduce the severity of the symptoms.<ref name=Lancet2004 /> Use of antibiotics also reduces fluid requirements.<ref>{{cite report|date=November 28, 2011|title=Cholera Treatment|url=https://www.cdc.gov/cholera/treatment/index.html|publisher=Centers for Disease Control and Prevention (CDC)|url-status=live|archive-url=https://web.archive.org/web/20150311042338/http://www.cdc.gov/cholera/treatment/index.html|archive-date=March 11, 2015}}</ref> People will recover without them, however, if sufficient hydration is maintained.<ref name=NEJM2006 /> The WHO only recommends antibiotics in those with severe dehydration.<ref name=choleraoutbreaksteps>{{cite web|title=First steps for managing an outbreak of acute diarrhea|url=https://www.who.int/topics/cholera/publications/en/first_steps.pdf|publisher=World Health Organization Global Task Force on Cholera Control|access-date=November 23, 2013|url-status=live|archive-url=https://web.archive.org/web/20140805150434/http://www.who.int/topics/cholera/publications/en/first_steps.pdf|archive-date=August 5, 2014}}</ref>

[[Doxycycline]] is typically used first line, although some [[Strain (biology)|strains]] of ''V.&nbsp;cholerae'' have shown [[Antibiotic resistance|resistance]].<ref name=Lancet2004 /> Testing for resistance during an outbreak can help determine appropriate future choices.<ref name=Lancet2004 /> Other antibiotics proven to be effective include [[cotrimoxazole]], [[erythromycin]], [[tetracycline]], [[chloramphenicol]], and [[furazolidone]].<ref>{{cite web |archive-url=https://web.archive.org/web/20121106021041/http://sprojects.mmi.mcgill.ca/tropmed/disease/chol/treatment.htm|archive-date=6 November 2012|url=http://sprojects.mmi.mcgill.ca/tropmed/disease/chol/treatment.htm |title=Cholera treatment|publisher=Molson Medical Informatics |year=2007 |access-date=2008-01-03}}</ref> [[Fluoroquinolone]]s, such as [[ciprofloxacin]], also may be used, but resistance has been reported.<ref>{{cite journal | vauthors = Krishna BV, Patil AB, Chandrasekhar MR | title = Fluoroquinolone-resistant Vibrio cholerae isolated during a cholera outbreak in India | journal = Transactions of the Royal Society of Tropical Medicine and Hygiene | volume = 100 | issue = 3 | pages = 224–6 | date = March 2006 | pmid = 16246383 | doi = 10.1016/j.trstmh.2005.07.007 }}</ref>

Antibiotics improve outcomes in those who are both severely and not severely dehydrated.<ref name="Lei2014">{{cite journal | vauthors = Leibovici-Weissman Y, Neuberger A, Bitterman R, Sinclair D, Salam MA, Paul M | title = Antimicrobial drugs for treating cholera | journal = The Cochrane Database of Systematic Reviews | issue = 6 | pages = CD008625 | date = June 2014 | volume = 2014 | pmid = 24944120 | pmc = 4468928 | doi = 10.1002/14651858.CD008625.pub2 }}</ref> [[Azithromycin]] and [[tetracycline]] may work better than [[doxycycline]] or [[ciprofloxacin]].<ref name="Lei2014" />