Editing Tetracycline (section)

==Research==
===Genetic engineering===
In [[genetic engineering]], tetracycline is used in [[Tetracycline-controlled transcriptional activation|transcriptional activation]]. It has been used as an engineered "control switch" in [[chronic myelogenous leukemia]] models in mice. Engineers were able to develop a retrovirus that induced a particular type of leukemia in mice, and could then "switch" the cancer on and off through tetracycline administration. This could be used to grow the cancer in mice and then halt it at a particular stage to allow for further experimentation or study.<ref>{{Cite journal |vauthors=Dugray A, Geay JF, Foudi A, Bonnet ML, Vainchenker W, Wendling F, Louache F, Turhan AG |date=October 2001 |title=Rapid generation of a tetracycline-inducible BCR-ABL defective retrovirus using a single autoregulatory retroviral cassette |journal=Leukemia |volume=15 |issue=10 |pages=1658–1662 |doi=10.1038/sj.leu.2402225 |pmid=11587226 |s2cid=40155100}}</ref>

A technique being developed for the control of the [[mosquito]] species ''[[Aedes aegypti]]'' (the infection [[Vector (epidemiology)|vector]] for [[yellow fever]], [[dengue fever]], [[Zika fever]], and several other diseases) uses a strain that is [[genetically modified]] to require tetracycline to develop beyond the larval stage. Modified males raised in a laboratory develop normally as they are supplied with this chemical and can be released into the wild. Their subsequent offspring inherit this trait, but find no tetracycline in their environments, so never develop into adults.<ref>{{Cite news |date=15 July 2012 |title=Can GM mosquitoes rid the world of a major killer? |url=https://www.theguardian.com/environment/2012/jul/15/gm-mosquitoes-dengue-fever-feature |url-status=live |archive-url=https://web.archive.org/web/20131205105805/http://www.theguardian.com/environment/2012/jul/15/gm-mosquitoes-dengue-fever-feature |archive-date=5 December 2013 |access-date=15 July 2012 |work=The Observer |vauthors=Urquhart C}}</ref>