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==Prevention== Prevention of peptic ulcer disease for those who are taking NSAIDs (with low cardiovascular risk) can be achieved by adding a [[proton pump inhibitor]] (PPI), an [[H2 antagonist]], or [[misoprostol]].<ref name="Angel 2017"/> NSAIDs of the COX-2 inhibitors type may reduce the rate of ulcers when compared to non-selective NSAIDs.<ref name="Angel 2017"/> PPI is the most popular agent in peptic ulcer prevention.<ref name="Angel 2017"/> However, there is no evidence that H2 antagonists can prevent stomach bleeding for those taking NSAIDs.<ref name="Angel 2017"/> Although misoprostol is effective in preventing peptic ulcer, its properties of promoting abortion and causing gastrointestinal distress limit its use.<ref name="Angel 2017"/> For those with high cardiovascular risk, naproxen with PPI can be a useful choice.<ref name="Angel 2017"/> Otherwise, low-dose aspirin, celecoxib, and PPI can also be used.<ref name="Angel 2017"/>
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