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==== United States ==== The [[Occupational Safety and Health Administration]] (OSHA) is the regulatory body covering worker safety. OSHA puts forth permissible exposure limit (PEL) 20 ppb for MDI and detailed technical guidance on exposure assessment.<ref name=":6" /> The National Institutes of Health ([[National Institute for Occupational Safety and Health|NIOSH]]) is the agency responsible for providing the research and recommendations regarding workplace safety, while OSHA is more of an enforcement body. NIOSH is responsible for producing the science that can result in recommended exposure limits (REL), which can be lower than the PEL. OSHA is tasked with enforcement and defending the enforceable limits (PELs). In 1992, when OSHA reduced the PEL for TDI to the NIOSH REL, the PEL reduction was challenged in court, and the reduction was reversed.<ref name=":7">{{Cite journal |date=1996-03-01 |title=Request for assistance in preventing asthma and death from diisocyanate exposure |url=https://www.cdc.gov/niosh/docs/96-111/default.html |language=en-us |doi=10.26616/NIOSHPUB96111|doi-access=free }}</ref> The Environmental Protection Agency ([[United States Environmental Protection Agency|EPA]]) is also involved in the regulation of isocyanates with regard to the environment and also non-worker persons that might be exposed.<ref>{{Cite web |url=https://www.epa.gov/saferchoice/spray-polyurethane-foam-spf-insulation-and-how-use-it-more-safely |title=Spray Polyurethane Foam (SPF) Insulation and How to Use it More Safely |author=US EPA, OCSPP, OPPT, EETD |website=US EPA |date=2015-06-06 |language=en |access-date=2018-11-22}}</ref> The [[American Conference of Governmental Industrial Hygienists]] (ACGIH) is a non-government organization that publishes guidance known as threshold limit values (TLV)<ref name=":7" /> for {{clarify span|chemicals based research as constant work exposure level without ill-effect|date=August 2019}}. The TLV is not an OSHA-enforceable value, unless the PEL is the same.
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