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Dendritic cell
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==Other animals== The above applies to humans. In other organisms, the function of dendritic cells can differ slightly. However, the principal function of dendritic cells as known to date is always to act as an immune sentinel. They survey the body and collect information relevant to the immune system, they are then able to instruct and direct the adaptive arms to respond to challenges. In addition, an immediate precursor to myeloid and lymphoid dendritic cells of the spleen has been identified.<ref name=Naik>{{cite journal |vauthors=Naik SH, Metcalf D, van Nieuwenhuijze A, etal | journal=Nature Immunology | title=Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes |date=June 2006 | volume=7 | issue=6 | pages=663–71 | doi=10.1038/ni1340 | pmid=16680143| s2cid=539437 }}</ref> This precursor, termed pre-DC, lacks MHC class II surface expression, and is distinct from monocytes, which primarily give rise to DCs in non-lymphoid tissues. Dendritic cells have also been found in turtles.<ref>{{cite journal | last=Pérez-Torres | first=A |author2=Millán-Aldaco DA |author3=Rondán-Zárate A | title=Epidermal Langerhans cells in the terrestrial turtle, ''Kinosternum integrum'' | journal=Developmental and Comparative Immunology | volume=19 | issue=3 | pages=225–236 |date=May–June 1995 | pmid=8595821 | doi=10.1016/0145-305X(95)00006-F }}</ref> Dendritic cells have been found in rainbow trout (''Oncorhynchus mykiss'') and zebrafish (''Danio rerio'') but their role is still not fully understood <ref>Salinas, I., & Parra, D. (2015). Fish mucosal immunity: Intestine. In Mucosal Health in Aquaculture. Elsevier Inc. https://doi.org/10.1016/B978-0-12-417186-2.00006-6</ref>
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