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==Intravenous therapy== Colloid solutions used in [[intravenous therapy]] belong to a major group of [[volume expander]]s, and can be used for intravenous [[fluid replacement]]. Colloids preserve a high [[colloid osmotic pressure]] in the blood,<ref name="gregory">{{Cite web|url=http://www.medscape.org/viewarticle/503138|title=An Update on Intravenous Fluids|last=Martin|first=Gregory S.|date=19 April 2005|website=[[Medscape]]|access-date=6 July 2016}}</ref> and therefore, they should theoretically preferentially increase the [[intravascular volume]], whereas other types of volume expanders called [[crystalloid solution|crystalloid]]s also increase the [[interstitial volume]] and [[intracellular volume]]. However, there is still controversy to the actual difference in [[efficacy]] by this difference,<ref name=gregory/> and much of the research related to this use of colloids is based on fraudulent research by [[Joachim Boldt]].<ref>{{Cite news|url=https://www.telegraph.co.uk/health/8360667/Millions-of-surgery-patients-at-risk-in-drug-research-fraud-scandal.html|title=Millions of surgery patients at risk in drug research fraud scandal|last=Blake|first=Heidi|date=3 March 2011|newspaper=The Telegraph|location=UK|archive-url=https://web.archive.org/web/20111104083124/http://www.telegraph.co.uk/health/8360667/Millions-of-surgery-patients-at-risk-in-drug-research-fraud-scandal.html|archive-date=4 November 2011|url-status=dead|access-date=4 November 2011}}</ref> Another difference is that crystalloids generally are much cheaper than colloids.<ref name=gregory/>
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