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==Health-related research== Cinnamon has a long history of use in [[traditional medicine]] as a digestive aid. However, contemporary studies are unable to find evidence of any significant medicinal or therapeutic effect.<ref name="nccih">{{cite web|url=https://nccih.nih.gov/health/cinnamon|title=Cinnamon|website=[[National Center for Complementary and Integrative Health]]|publisher=[[National Institutes of Health]]|date=2016|access-date=28 February 2017|archive-date=1 March 2017|archive-url=https://web.archive.org/web/20170301111423/https://nccih.nih.gov/health/cinnamon|url-status=live}}</ref> Reviews of clinical trials reported lowering of fasting [[plasma glucose]] and inconsistent effects on [[hemoglobin A1C]] (HbA1c, an indicator of chronically elevated plasma glucose).<ref name=Costello2016>{{cite journal|first1=Rebecca B.|last1=Costello|first2=Johanna T.|last2=Dwyer|first3=Leila|last3=Saldanha|first4=Regan L.|last4=Bailey|first5=Joyce|last5=Merkel|first6=Edwina|last6=Wambogo|title=Do Cinnamon Supplements Have a Role in Glycemic Control in Type 2 Diabetes? A Narrative Review|journal=[[Journal of the Academy of Nutrition and Dietetics]]|volume=116|issue=11|pages=1794β1802|date=2016|pmid=27618575|pmc=5085873|doi=10.1016/j.jand.2016.07.015}}</ref><ref name=Allen2013>{{cite journal|first1=Robert W.|last1=Allen|first2=Emmanuelle|last2=Schwartzman|first3=William L.|last3=Baker|first4=Craig I.|last4=Coleman|first5=Olivia J.|last5=Phung|title=Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis|journal=[[The Annals of Family Medicine]]|volume=11|issue=5|pages=452β459|date=2013|pmid=24019277|pmc=3767714|doi=10.1370/afm.1517}}</ref><ref name=Akilen2012>{{cite journal|last1=Akilen|first1=Rajadurai|last2=Tsiami|first2=Amalia|last3=Devendra|first3=Devasenan|last4=Robinson|first4=Nicola|title=Cinnamon in glycaemic control: Systematic review and meta analysis|journal=[[Clinical Nutrition (journal)|Clinical Nutrition]]|volume=31|issue=5|pages=609β615|date=20 April 2012|pmid=22579946|doi=10.1016/j.clnu.2012.04.003}}</ref><ref name=Leach2012>{{cite journal|last1=Leach|first1=Matthew J.|last2=Kumar|first2=Saravana|title=Cinnamon for diabetes mellitus|journal=[[Cochrane Database of Systematic Reviews]]|issue=9|date=12 September 2012|volume=2012 |pages=CD007170|pmid=22972104|doi=10.1002/14651858.CD007170.pub2|pmc=6486047}}</ref><ref name=Namazi2019>{{cite journal|last1=Namazi|first1=Nazli|last2=Khodamoradi|first2=Kajal|last3=Khamechi|first3=Seyed Peyman|last4=Heshmati|first4=Javad|last5=Ayati|first5=Mohammad Hossein|last6=Larijani|first6=Bagher|title=The impact of cinnamon on anthropometric indices and glycemic status in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials|journal=[[Complementary Therapies in Medicine]]|volume=43|pages=92β101|date=April 2019|pmid=30935562|doi=10.1016/j.ctim.2019.01.002|s2cid=81727505}}</ref> Four of the reviews reported a decrease in fasting plasma glucose,<ref name=Costello2016/><ref name=Allen2013/><ref name=Akilen2012/><ref name=Namazi2019/> only two reported lower HbA1c,<ref name=Costello2016/><ref name=Akilen2012/> and one reported no change to either measure.<ref name=Leach2012/> The [[Cochrane (organisation)|Cochrane]] review noted that trial durations were limited to 4 to 16 weeks, and that no trials reported on changes to [[quality of life]], [[morbidity]] or [[mortality rate]]. The Cochrane authors' conclusion was: "There is insufficient evidence to support the use of cinnamon for type 1 or type 2 [[diabetes mellitus]]."<ref name=Leach2012/> Citing the Cochrane review, the U.S. [[National Center for Complementary and Integrative Health]] stated: "Studies done in people don't support using cinnamon for any health condition."<ref name=nccih/> However, the results of the studies are difficult to interpret because it is often unclear what type of cinnamon and what part of the plant were used.<ref>{{cite web|url=https://www.nccih.nih.gov/health/cinnamon|title=Cinnamon|access-date=20 June 2021|archive-date=25 June 2021|archive-url=https://web.archive.org/web/20210625060646/https://www.nccih.nih.gov/health/cinnamon|url-status=live}}</ref> A meta-analysis of cinnamon supplementation trials with lipid measurements reported lower total cholesterol and triglycerides, but no significant changes in [[LDL-cholesterol]] or [[HDL-cholesterol]].<ref>{{cite journal |vauthors=Maierean SM, Serban MC, Sahebkar A, Ursoniu S, Serban A, Penson P, Banach M |title=The effects of cinnamon supplementation on blood lipid concentrations: A systematic review and meta-analysis |journal=J Clin Lipidol |volume=11 |issue=6 |pages=1393β1406 |date=2017 |pmid=28887086 |doi=10.1016/j.jacl.2017.08.004 |url=http://researchonline.ljmu.ac.uk/6931/1/cinnamon.pdf |access-date=27 November 2018 |archive-date=28 April 2019 |archive-url=https://web.archive.org/web/20190428043735/http://researchonline.ljmu.ac.uk/6931/1/cinnamon.pdf |url-status=live }}</ref> Another reported no change to body weight or insulin resistance.<ref name=Namazi2019/>
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