Editing Chemotherapy (section)

=== Nausea and vomiting ===
{{Further|Chemotherapy-induced nausea and vomiting}}
[[Nausea]] and [[vomiting]] are two of the most feared cancer treatment-related side-effects for people with cancer and their families. In 1983, Coates et al. found that people receiving chemotherapy ranked nausea and vomiting as the first and second most severe side-effects, respectively.<ref>{{Citation |last=PDQ Supportive and Palliative Care Editorial Board |title=Nausea and Vomiting Related to Cancer Treatment (PDQ®): Health Professional Version |date=2002 |url=http://www.ncbi.nlm.nih.gov/books/NBK66056/ |work=PDQ Cancer Information Summaries |place=Bethesda (MD) |publisher=National Cancer Institute (US) |pmid=26389491 |access-date=2022-11-08}}</ref> Up to 20% of people receiving highly emetogenic agents in this era postponed, or even refused potentially curative treatments.<ref>{{cite journal | title = Nausea and Vomiting in the Cancer Patient | year = 2006 | journal = Oncology | pages = 1482–1496 | doi = 10.1007/0-387-31056-8_83 | quote = Nausea and vomiting are two of the most feared cancer treatment-related side effects for cancer patients and their families. | last1 = Gill | first1 = Paula | last2 = Grothey | first2 = Axel | last3 = Loprinzi | first3 = Charles | name-list-style = vanc | isbn = 978-0-387-24291-0 }}</ref> Chemotherapy-induced nausea and vomiting (CINV) are common with many treatments and some forms of cancer. Since the 1990s, several novel classes of [[antiemetics]] have been developed and commercialized, becoming a nearly universal standard in chemotherapy regimens, and helping to successfully manage these symptoms in many people. Effective mediation of these unpleasant and sometimes debilitating symptoms results in increased quality of life for the recipient and more efficient treatment cycles, as patients are less likely to avoid or refuse treatment.<ref>{{Cite journal |last1=Sanger |first1=Gareth J. |last2=Andrews |first2=Paul L. R. |date=2018-09-04 |title=A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research |journal=Frontiers in Pharmacology |volume=9 |pages=913 |doi=10.3389/fphar.2018.00913 |issn=1663-9812 |pmc=6131675 |pmid=30233361|doi-access=free }}</ref>